Association of gastroesophageal reflux disease and laryngeal cancer.
Association of gastroesophageal reflux disease and laryngeal cancer.
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DOI：
10.1016/j.wjorl.2017.12.011
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发表时间：
2018-12-01
期刊：
影响因子：
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通讯作者：
Soliman, Ahmed M S
中科院分区：
文献类型：
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作者：
Anis, Mursalin M;Razavi, Mir-Muhammad;Soliman, Ahmed M S
目的：反流性疾病与发展喉癌的风险的研究都证明和反驳了无效hypothesis.METHODS：这一回顾性病例对照研究探讨了反流在两个人群暴露于类似的危险因素，包括烟草，在一定程度上，终末器官恶性转化已经发生的关联。在获得IRB批准后，对2000年至2013年期间我院癌症中心的数据库进行了检索。然后进行回顾性图表分析，确定喉癌患者（n=290）中胃食管反流病的患病率。然后将其与同期肺癌患者（n=2440）中胃食管反流病的患病率进行比较。结果：考虑到吸烟的因素，男性与喉癌的发生有较强的相关性（OR=3.30，95%CI 2.53 - 4.36，P <0.01），而与肺癌的发生无相关性（OR=3.30，95%CI 2.53-4.36，P <0.05）。
OBJECTIVE: Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null hypothesis.METHODS: This retrospective case-control study examines the association of reflux in two populations exposed to similar risk factors, including tobacco, to the extent that end-organ malignant transformation has occurred. After IRB approval was obtained, a search of our hospital's cancer center's database was performed from 2000 to 2013. A retrospective chart review was then performed and the prevalence of gastroesophageal reflux disease among patients with laryngeal cancer (n=290) was determined. It was then compared to the prevalence of gastroesophageal reflux disease among patients presenting with lung cancer (n=2440) during the same time period. A multivariate logistic regression was performed to determine the association of reflux with laryngeal cancer.RESULTS: Taking into consideration tobacco use, there was a strong association between male gender and occurrence of laryngeal cancer as opposed to lung cancer (OR=3.30; 95% CI 2.53-4.36, P