Comparison of Simplified Parametric Methods for Visual Interpretation of 11C-Pittsburgh Compound-B PET Images
Comparison of Simplified Parametric Methods for Visual Interpretation of 11C-Pittsburgh Compound-B PET Images
复制标题
11C-匹兹堡化合物-B PET 图像视觉判读的简化参数方法的比较
DOI：
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发表时间：
2014
影响因子：
9.3
通讯作者：
B. V. van Berckel
中科院分区：
文献类型：
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作者：
M. Zwan;R. Ossenkoppele;N. Tolboom;A. Beunders;R. Kloet;S. Adriaanse;R. Boellaard;A. Windhorst;P. Raijmakers;H. Adams;A. Lammertsma;P. Scheltens;W. M. van der Flier;B. V. van Berckel
本研究比较了几种参数成像方法，以确定参数匹兹堡化合物-B (11C-PIB) PET 图像视觉评估的最佳方法，以检测不同记忆诊所患者组的皮质淀粉样蛋白沉积。方法：对120名记忆诊所患者进行动态11C-PIB扫描。将参数不可置换结合电位 (BPND) 图像与标准化摄取值 (SUV) 和 SUV 比率图像进行比较。图像由 3 名独立读者进行视觉评估，并确定读者间和方法间的一致性。结果：90 分钟（Fleiss κ = 0.88）和 60 分钟（Fleiss κ = 0.89）BPND 图像均显示出良好的读者间一致性，而 SUV 比率图像（Fleiss κ = 0.68）和 SUV 图像（Fleiss κ = 0.59）的一致性为良好至中等。尽管 BPND 图像始终表现出最佳性能，但读者之间的方法间一致性差异很大。结论：BPND 图像的使用提供了最高的读码器间和方法间一致性，因此是 11C-PIB PET 扫描最佳视觉判读的首选方法。
This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B (11C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups. Methods: Dynamic 11C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined. Results: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance. Conclusion: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of 11C-PIB PET scans.
影响因子：
14.5
作者：
Rascovsky, Katya;Hodges, John R.;Miller, Bruce L.
通讯作者：
Miller, Bruce L.