Immunomodulatory effects of allogeneic blood transfusions: Clinical manifestations and mechanisms
Immunomodulatory effects of allogeneic blood transfusions: Clinical manifestations and mechanisms
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DOI：
10.1111/j.1423-0410.1998.tb05437.x
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发表时间：
1998-01-01
期刊：
影响因子：
2.7
通讯作者：
Blajchman, MA
中科院分区：
文献类型：
--
作者：
Blajchman, MA
异体输血相关的免疫调节可增加异体输血个体的发病率，这一认识已成为输血医学相关人员关注的主要问题。然而，同种异体输血是否会增加癌症复发或细菌感染的风险仍未得到证实。相反，来自实验动物模型的研究数据表明，与异体输血相关的免疫调节是一种免疫介导的生物学效应，主要与异体白细胞的输注有关。此外，现有的实验动物数据表明，与储存后的白细胞减少相比，储存前的白细胞减少能有效地改善同种异体血液的肿瘤生长促进作用。虽然已经积累了大量的数据，试图揭示同种异体输血免疫调节作用的机制，但这种作用的确切机制尚未阐明。
Recognition that allogeneic transfusion associated immunomodulation can increase morbidity in allogeneically transfused individuals has become a major concern for those involved in transfusion medicine. However, whether allogeneic blood transfusions predispose recipients to increased risk for cancer recurrence or to bacterial infections is still unproven. In contrast, data from studies in experimental animal models suggest that allogeneic blood transfusion associated immunomodulation is an immunologically mediated biological effect which is associated primarily with the infusion of allogeneic leukocytes. Moreover, the available experimental animal data suggest that pre-storage leukoreduction, as opposed to post-storage leukodepletion, is effective in ameliorating this tumor growth-enhancing effect of allogeneic blood. While considerable data have accumulated in an attempt to unravel the mechanism of the immunomodulatory effect of allogeneic blood transfusions, the precise mechanism of this effect has not yet been elucidated.