Validation of a Multimodality Flow Phantom and Its Application for Assessment of Dynamic SPECT and PET Technologies
Validation of a Multimodality Flow Phantom and Its Application for Assessment of Dynamic SPECT and PET Technologies
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DOI：
10.1109/tmi.2016.2599779
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发表时间：
2017-01-01
影响因子：
10.6
通讯作者：
Klein, Ran
中科院分区：
文献类型：
--
作者：
Gabrani-Juma, Hanif;Clarkin, Owen J.;Klein, Ran
缺乏简单和鲁棒的技术来评估使用动态成像的流量量化的性能。因此，我们开发了一种方法，使用物理隔室交换体模和图像分析工具来鉴定流量量化技术。我们使用动态PET和SPECT验证并证明了该方法的实用性。在两个PET/CT和心脏专用SPECT（有和没有衰减和散射校正）系统上采集动态图像序列。将二室交换模型拟合到图像导出的时间-活性曲线以量化流速。在成像之前设置流量计测量的流速（20-300 mL/min），并将其用作参考真实值，与图像导出的流速进行比较。两种PET相机均与真实值具有良好的一致性（r（2）> 0.94）。高端PET无显著偏倚（p > 0.05），而低端PET的斜率偏倚最小（洗入和洗出斜率分别为1.02和1.01），但相对于高端PET，精密度无显著降低（
Simple and robust techniques are lacking to assess performance of flow quantification using dynamic imaging. We therefore developed a method to qualify flow quantification technologies using a physical compartment exchange phantom and image analysis tool. We validate and demonstrate utility of this method using dynamic PET and SPECT. Dynamic image sequences were acquired on two PET/CT and a cardiac dedicated SPECT (with and without attenuation and scatter corrections) systems. A two-compartment exchange model was fit to image derived time-activity curves to quantify flow rates. Flowmeter measured flow rates (20-300 mL/min) were set prior to imaging and were used as reference truth to which image derived flow rates were compared. Both PET cameras had excellent agreement with truth (r(2) > 0.94). High-end PET had no significant bias (p > 0.05) while lower-end PET had minimal slope bias (wash-in and wash-out slopes were 1.02 and 1.01) but no significant reduction in precision relative to high-end PET (