INCREASED DYNORPHIN IMMUNOREACTIVITY IN SPINAL-CORD AFTER TRAUMATIC INJURY
INCREASED DYNORPHIN IMMUNOREACTIVITY IN SPINAL-CORD AFTER TRAUMATIC INJURY
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DOI：
10.1016/0167-0115(85)90029-1
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发表时间：
1985-01-01
影响因子：
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通讯作者：
COX, BM
中科院分区：
文献类型：
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作者：
FADEN, AI;MOLINEAUX, CJ;COX, BM
高剂量的阿片拮抗剂已被证明可以改善实验性脊髓损伤后的生理变量和结果。Dynorphi似乎是唯一的阿片类药物在鞘内注射后产生后肢瘫痪。内源性阿片类物质，特别是强啡肽，在脊髓损伤中可能的病理生理作用。本实验观察了大鼠脊髓创伤后强啡肽免疫反应性（Dyn-ir）的变化及其与运动功能障碍的关系。创伤与损伤部位Dyn-ir显著增加相关，但与病变距离无关。Dyn-ir在伤后2 h、2 wk即开始升高，并与损伤程度密切相关。显然，强啡肽系统可能参与脊髓创伤后的继发性损伤。
Opiate antagonists, at high doses, have been shown to improve physiological variables and outcome after experimental spinal injury. Dynorphi appears to be unique among opioids in producing hindlimb paralysis after intrathecal injection. A possible pathophysiological role for endogenous opioids, particularly dynorphin, in spinal injury was suggested. The relationship between changes in dynorphin immunoreactivity (Dyn-ir) in rat spinal cord after traumatic injury and the subsequent motor dysfunction was examined. Trauma was associated with significantly increased Dyn-ir at the injury site, but not distant from the lesion. Dyn-ir was found elevated as early as 2 h and as late as 2 wk after trauma and was signifcantly correlated with the degree of injury. Apparently, dynorphin systems may be involved in the secondary injury that follows spinal trauma.