An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
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DOI：
10.1016/s0896-6273(00)80647-9
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发表时间：
1998-12-01
期刊：
影响因子：
16.2
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Bulfone, A;Wang, F;Rubenstein, JLR
表达特定气味受体的嗅觉神经元投射到嗅球中的两个拓扑固定的肾小球。我们已经研究了不同类型的细胞在嗅球的建立这一地形图的贡献。具有Tbr-1纯合缺陷的小鼠缺乏大多数投射神经元，而具有Dlx-1和Dlx-2纯合缺陷的小鼠缺乏大多数GABA能中间神经元。携带P2-IRES-tau-lacZ等位基因并且缺乏Tbr-1或Dlx-1/Dlx-2的小鼠揭示了轴突在与野生型小鼠中观察到的位置类似的位置处会聚到一个内侧和一个外侧位点。这些观察结果表明，地形图的建立并不依赖于嗅球中主要神经元细胞类型提供的线索或突触形成。
Olfactory sensory neurons expressing a given odorant receptor project to two topographically fixed glomeruli in the olfactory bulb. We have examined the contribution of different cell types in the olfactory bulb to the establishment of this topographic map. Mice with a homozygous deficiency in Tbr-1 lack most projection neurons, whereas mice with a homozygous deficiency in Dlx-1 and Dlx-2 lack most GABAergic interneurons. Mice bearing a P2-IRES-tau-lacZ allele and deficient in either Tbr-1 or Dlx-1/Dlx-2 reveal the convergence of axons to one medial and one lateral site at positions analogous to those observed in wild-type mice. These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb.