Human placentation from nidation to 5 weeks of gestation. Part II: Tools to model the crucial first days
Human placentation from nidation to 5 weeks of gestation. Part II: Tools to model the crucial first days
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DOI：
10.1016/j.placenta.2012.01.019
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发表时间：
2012-05-01
期刊：
影响因子：
3.8
通讯作者：
Chamley, L. W.
中科院分区：
文献类型：
--
作者：
James, J. L.;Carter, A. M.;Chamley, L. W.
人类妊娠在每月自发蜕膜化以及胎盘侵入程度以及与蜕膜化子宫内膜基质的相互作用方面是不寻常的。本综述涵盖了体内动物模型和体外细胞培养模型，这些模型已用于研究人类着床和胎盘从着床到妊娠 5 周的最早阶段。近年来，由于人类胚胎干细胞系的产生以及一些科学家培养人类囊胚的能力，该领域迅速扩展。这些模型使研究人员能够开始阐明人类囊胚并置、粘附和植入中涉及的相互作用。然而，我们对胎盘形成所涉及的分化过程仍然知之甚少。对当前模型的持续改进，包括人类滋养层干细胞的潜在分离，将显着增强我们定义人类植入和早期胎盘发育过程中发生的分子和结构事件的能力。 (C) 2012 Elsevier Ltd. 保留所有权利。
Human pregnancy is unusual with respect to monthly spontaneous decidualisation as well as the degree of placental invasion and interaction with the decidualised endometrial stroma. This review covers in vivo animal models and in vitro cell culture models that have been used to study the earliest stages of human implantation and placentation from nidation to 5 weeks of gestation. The field has expanded rapidly in recent years due to the generation of human embryonic stem cell lines and the ability of some scientists to culture human blastocysts. These models have enabled researchers to begin to elucidate the interactions involved in human blastocyst apposition, adhesion and implantation. However, we still understand very little about the differentiation processes involved in the formation of the placenta. Continued improvements to current models, including the potential isolation of a human trophoblast stem cell, will significantly enhance our ability to define the molecular and structural events occurring during human implantation and early placental development. (C) 2012 Elsevier Ltd. All rights reserved.