3-DIMENSIONAL STRUCTURE OF CALMODULIN
3-DIMENSIONAL STRUCTURE OF CALMODULIN
复制标题
DOI：
10.1038/315037a0
复制
发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
COOK, WJ
中科院分区：
文献类型：
--
作者：
BABU, YS;SACK, JS;COOK, WJ
钙调素[大鼠]的三维结构在3.0埃下用晶体学方法测定。分辨率该分子由2个球状裂片组成，球状裂片通过长的暴露的α-螺旋。每个叶通过螺旋-环-螺旋结构域结合2个Ca离子，类似于其他Ca结合蛋白。叶之间的长螺旋可能参与钙调素与药物和各种蛋白质的相互作用。
The 3-dimensional structure of calmodulin [rat] was determined crystallographically at 3.0 .ANG. resolution. The molecule consits of 2 globular lobes connected by a long exposed .alpha.-helix. Each lobe binds 2 Ca ions through helix-loop-helix domains similar to those of other Ca-binding proteins. The long helix between the lobes may be involved in interactions of calmodulin with drugs and various proteins.