Use of PSA-NCAM in Repair of the Central Nervous System
Use of PSA-NCAM in Repair of the Central Nervous System
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DOI：
10.1007/978-1-4419-1170-4_9
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Rutishauser, Urs
中科院分区：
文献类型：
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作者：
El Maarouf, Abderrahman;Rutishauser, Urs
聚唾液酸（PSA）是一种高度水合的聚合物，其存在于细胞表面可以减少细胞间的相互作用，从而增加组织和细胞的可塑性。鉴于其为细胞迁移和轴突生长创造一个有利环境的能力，已经在成人中枢神经系统中探索了工程化过表达PSA促进组织修复的潜力。一些有希望的结果表明，PSA工程可能成为一种有价值的治疗工具。
Polysialic acid (PSA) is a highly hydrated polymer whose presence at the cell surface can reduce cell interactions, and thereby increase tissue and cellular plasticity. Given its ability to create a permissive environment for cell migration and axonal growth, the potential of engineered overexpression of PSA to promote tissue repair has been explored in the adult CNS. Several promising results have been obtained that suggest that PSA engineering may become a valuable therapeutic tool.