Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone
Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone
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DOI：
10.1016/j.brainresbull.2005.05.028
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发表时间：
2005-09-30
影响因子：
3.8
通讯作者：
Ho, IK
中科院分区：
文献类型：
--
作者：
Chiu, CT;Ma, TG;Ho, IK
反复间歇性暴露于精神兴奋剂被发现产生行为敏化。本研究旨在建立小鼠模型，探讨阿片系统在甲基苯丙胺行为敏化中的作用。连续7天每天一次注射2.5 mg/kg甲基苯丙胺的小鼠在第11天用0.3125 mg/kg药物激发后表现出行为敏化，而注射较低日剂量（1.25 mg/kg）的小鼠则没有。每天注射1.25或2.5 mg/kg甲基苯丙胺的小鼠在第11、21和28天用1.25 mg/kg药物激发后表现出行为敏化。为了研究阿片系统在行为敏化诱导和表达中的作用，分别在每天注射甲基苯丙胺和用甲基苯丙胺激发之前给予长效但非选择性阿片拮抗剂纳洛酮。我们的研究结果表明，行为敏化的表达减弱预处理与10或20 mg/kg的纳洛酮无论是在诱导期或前甲基苯丙胺的挑战时，他们在第11和21天进行了测试。这些结果表明，重复注射甲基苯丙胺剂量依赖性地诱导小鼠的行为敏化，并建议阿片受体参与甲基苯丙胺诱导的行为敏化的诱导和表达。(c)2005年由Elsevier Inc.出版
Repeated intermittent exposure to psychostimulants was found to produce behavioral sensitization. The present study was designed to establish a mouse model and by which to investigate whether opioidergic system plays a role in methamphetamine-induced behavioral sensitization. Mice injected with 2.5 mg/kg of methamphetamine once a day for 7 consecutive days showed behavioral sensitization after challenge with 0.3125 mg/kg of the drug on day 11, whereas mice injected with a lower daily dose (1.25 mg/kg) did not. Mice received daily injections with either 1.25 or 2.5 mg/kg of methamphetamine showed behavioral sensitization after challenge with 1.25 mg/kg of the drug on days 11, 21, and 28. To investigate the role of opioidergic system in the induction and expression of behavioral sensitization, long-acting but non-selective opioid antagonist naltrexone was administrated prior to the daily injections of and challenge with methamphetamine, respectively. Our results show that the expressions of behavioral sensitization were attenuated by pretreatment with 10 or 20 mg/kg of naltrexone either during the induction period or before methamphetamine challenge when they were tested on days 11 and 21. These results indicate that repeated injection with methamphetamine dose-dependently induced behavioral sensitization in mice, and suggest the involvement of opioid receptors in the induction and expression of methamphetamine-induced behavioral sensitization. (c) 2005 Published by Elsevier Inc.