Effects of carbon-based nanomaterials on vascular endothelia under physiological and pathological conditions: interactions, mechanisms and potential therapeutic applications.
Effects of carbon-based nanomaterials on vascular endothelia under physiological and pathological conditions: interactions, mechanisms and potential therapeutic applications.
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DOI：
10.1016/j.jconrel.2020.10.067
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发表时间：
2020-11
期刊：
影响因子：
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通讯作者：
Yanli Zhang;Yulin Zhang;Junrong Wu;Jia Liu;Yiyuan Kang;Chen Hu;Xiaoli Feng;Wenjing Liu;
中科院分区：
文献类型：
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作者：
Yanli Zhang;Yulin Zhang;Junrong Wu;Jia Liu;Yiyuan Kang;Chen Hu;Xiaoli Feng;Wenjing Liu;
内皮细胞参与维持血管止血并参与多种病理过程。尽管内皮很少是靶组织，但它与应用的治疗系统密切相互作用。碳纳米材料（CBN）具有可编辑的理化特性和突出的生物安全性，被认为在生物医学领域具有广阔的前景。在到达目的地之前，这些材料必然进入血管并与血管内皮相互作用，这强烈影响生物医学效率。在这项工作中，我们从CBN引起的生理内皮屏障的变化开始，然后整理揭示的潜在机制。随后，我们讨论了影响CBN-内皮相互作用的因素，并强调了平衡治疗效率和生物相容性的重要性。更重要的是，这项工作介绍了多种血管内皮细胞在生理和病理条件下的异质性及其相关应用，希望促进未来治疗系统的准确性和疗效的提高。通过这份手稿，我们希望有助于阐明CBN血管研究的现状，并通过我们从当前优秀案例中获得的见解激发进一步令人兴奋的进展。
The endothelium participates in maintaining vascular hemostasis and is involved in multiple pathological processes. Although it is rarely the targeted tissue, the endothelium interacts intimately with applied therapeutic systems. Carbon nanomaterials (CBNs) with editable physiochemical characteristics and outstanding biosafety are believed to have great prospects in the biomedical field. Before reaching their destination, these materials necessarily enter the blood vessels and interact with the vascular endothelium, which strongly affects the biomedical efficiency. In this work, we start with the changes that CBNs cause to physiological endothelial barriers and then organize the potential mechanisms revealed. Subsequently, we discuss the factors influencing the CBN-endothelium interaction and highlight the importance of balancing therapeutic efficiency and biocompatibility. More importantly, this work introduces the heterogeneity of multiple vascular endothelia under both physiological and pathological conditions and the related applications with the hope of promoting improved accuracy and curative effects of future therapeutic systems. Through this manuscript, we hope to help illuminate the current status quo of CBN-vascular research and inspire further exciting progress via the insights we gained from the current outstanding examples.