Skeletal muscle dysfunction in chronic obstructive pulmonary disease
Skeletal muscle dysfunction in chronic obstructive pulmonary disease
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DOI：
10.1097/00005768-200107001-00004
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发表时间：
2001-07-01
期刊：
影响因子：
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通讯作者：
Casaburi, R
中科院分区：
文献类型：
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作者：
Casaburi, R
慢性阻塞性肺疾病患者的骨骼肌功能障碍。医学科学体育锻炼：第33卷。第7号，补编，pp. S662-S670。2001.慢性阻塞性肺疾病（COPD）是一个主要的卫生保健问题。以前主要是男性的疾病，现在越来越多的女性受到影响。在许多这些患者中，运动不耐受是主要的抱怨。有效的治疗方法很少。近年来，已确定肱二头肌的功能障碍是这些患者经历的运动不耐受的一部分的来源，并且这种功能障碍已被证明至少部分是可补救的。诱发肌肉功能障碍的机制包括废用性萎缩、营养不良、低水平的合成代谢类固醇和使用皮质类固醇引起的肌病。耐力运动训练已被最终证明可以提高COPD患者的运动耐量。最近的研究表明，力量训练也是有益的。COPD肌肉功能障碍治疗的一个新前沿是使用合成代谢激素。补充睾酮已被证明可以增加性腺功能减退和性腺功能正常的健康男性的肌肉质量和力量。低剂量睾酮补充剂正在考虑用于绝经后妇女。虽然短期给予中等剂量的睾酮在男性和女性中似乎耐受良好，但在确定COPD患者常规使用的安全性和有效性之前，还需要进一步的研究。
Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Med. Sci. Sports Exerc., Vol. 33. No. 7, Suppl., pp. S662-S670. 2001. Chronic obstructive pulmonary disease (COPD) is a major health care problem. Formerly mainly a disease of men, women are increasingly frequently afflicted. In many of these patients, exercise intolerance is the chief complaint. Few effective therapies are available. In recent years, dysfunction of the muscles of ambulation has been identified as a source of a portion of the exercise intolerance these patients experience, and this dysfunction has been shown to be, at least in part, remediable. Mechanisms inducing muscle dysfunction include disuse atrophy, malnutrition, low levels of anabolic steroids, and myopathy from corticosteroid use. Endurance exercise training has been conclusively demonstrated to improve exercise tolerance in COPD. Recent studies suggest that strength training is beneficial as well. A new frontier of therapy for muscle dysfunction in COPD is the use of anabolic hormones. Testosterone supplementation has been shown to increase muscle mass and strength in both hypogonadal and eugonodal healthy men. Low-dose testosterone supplementation is being considered for use in postmenopausal women. Though short-term administration of testosterone in moderate doses seems to be well tolerated in both men and women, further studies are required before safety and effectiveness can be established for routine use in COPD patients.