Prefrontal nicotinic receptors control novel social interaction between mice
Prefrontal nicotinic receptors control novel social interaction between mice
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DOI：
10.1096/fj.10-178558
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发表时间：
2011-07-01
期刊：
影响因子：
4.8
通讯作者：
Granon, Sylvie
中科院分区：
文献类型：
--
作者：
Avale, Maria Elena;Chabout, Jonathan;Granon, Sylvie
社会行为是哺乳动物的一个决定性特征，它将情感和动机过程与外部奖励刺激结合在一起。因此，它是一个适合复杂行为的读数，但它的神经元和分子基础仍然知之甚少。在这项研究中，我们研究了小鼠前额叶区域的作用，特别是β2亚单位尼古丁受体(β2*-nAChRs)在同时动机的社会行为范例中的参与。我们先前观察到，缺乏β2*-nAChRs(beta 2(-/-))的小鼠在社交接触中表现出更多的时间，并夸大地接近新的同种。在这里，结合行为分析、局部脑损伤和慢病毒基因拯救，我们发现c-Fos的表达在暴露于新型同种病毒的小鼠的前额叶皮质(PFC)的PRL区特异性激活；野生型小鼠PRL区的损伤产生与Beta 2(-/-)小鼠相同的社会模式；病毒介导的Beta 2亚单位在Beta 2(-/-)小鼠的PRL区的重新表达将社交互动任务中的行为成分拯救到正常水平。综上所述，这些数据表明，社会互动特别调动小鼠PFC的PRL区域，功能性PRLβ2*-nAChRs的存在对于这种整合行为的出现是必要的。-Avale，M.E.，Chabout，J.，Pons，S.，Serreau，P.，de Chauont，F.，Olivo-Marin，J-C.，Bourgeis，J-P.，Maskos，U，Changeux，J-P.，Granon，S.前额叶烟碱受体控制小鼠之间的新的社会互动。FASE B J.25,2145-2155(2011)。Www.fasebj.org
Social behavior is a defining mammalian feature that integrates emotional and motivational processes with external rewarding stimuli. It is thus an appropriate readout for complex behaviors, yet its neuronal and molecular bases remain poorly understood. In this study, we investigated the role of the mouse prefrontal area, particularly the involvement of beta 2-subunit nicotinic receptors (beta 2*-nAChRs) in a paradigm of social behavior with concurrent motivations. We previously observed that mice lacking beta 2*-nAChRs (beta 2(-/-)) display increased time in social contact and exaggerated approach movements toward the novel conspecific. Here, combining behavioral analysis, localized brain lesions, and lentiviral gene rescue, we found that c-Fos expression is specifically activated in the prelimbic (PrL) area of the prefrontal cortex (PFC) of mice exposed to a novel conspecific; lesions of the PrL area in wild-type mice produce the same social pattern as in beta 2(-/-) mice; and virally mediated reexpression of the beta 2-subunit in the PrL area of beta 2(-/-) mice rescues behavioral components in the social interaction task up to normal levels. Together, these data reveal that social interactions particularly mobilize the PrL area of the mouse PFC and that the presence of functional PrL beta 2*-nAChRs is necessary for this integrated behavior to emerge.-Avale, M. E., Chabout, J., Pons, S., Serreau, P., De Chauont, F., Olivo-Marin, J-C., Bourgeois, J-P., Maskos, U., Changeux, J-P., Granon, S. Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J. 25, 2145-2155 (2011). www.fasebj.org