Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.
Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.
复制标题
单克隆抗体中和α-溶血素和双组分杀白细胞素对金黄色葡萄球菌坏死性肺炎兔模型的保护作用。
DOI：
10.1128/aac.02220-19
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发表时间：
2020
影响因子：
4.9
通讯作者：
Diep,BinhAn
中科院分区：
文献类型：
--
作者：
Vu,TrangTT;Nguyen,NhuTQ;Tran,VuviG;Gras,Emmanuelle;Mao,Yanjie;Jung,DavidH;Tkaczyk,Christine;Sellman,BretR;Diep,BinhAn
金黄色葡萄球菌是一种主要的人类病原体，通过产生大量的细胞毒素引起广泛的感染。我们发现，用中和α-溶血素的单克隆抗体（MAb）或中和Panton-Valentine杀白细胞素、杀白细胞素艾德和γ-溶血素HlgAB和HlgCB的广泛交叉反应性MAb进行被动免疫仅提供部分保护，而这两种MAb的组合在由USA 300耐甲氧西林链球菌引起的坏死性肺炎的兔模型中提供显著保护。金黄色葡萄球菌流行性克隆
Staphylococcus aureus is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins. We found that passive immunization with either a monoclonal antibody (MAb) neutralizing alpha-hemolysin or a broadly cross-reactive MAb neutralizing Panton-Valentine leukocidin, leukocidin ED, and gamma-hemolysins HlgAB and HlgCB conferred only partial protection, whereas the combination of those two MAbs conferred significant protection in a rabbit model of necrotizing pneumonia caused by the USA300 methicillin-resistant S. aureus epidemic clone.