Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects
Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects
复制标题
DOI：
10.1291/hypres.31.75
复制
发表时间：
2008-01-01
影响因子：
5.4
通讯作者：
Sasaguri, Toshiyuki
中科院分区：
文献类型：
--
作者：
Ohmine, Takahiro;Miwa, Yoshikazu;Sasaguri, Toshiyuki
MRI上脑白色病变（WML）的存在被认为是血管性痴呆和卒中的预测因素。为了研究动脉僵硬度和白质损害之间的关系，我们对132名无症状的老年受试者进行了脑部MRI，以评估两种亚型的白质损害--脑室周围高信号（PVH）和深部白色病变（DWML）--的存在，并进一步确定了臂踝脉搏波速度（ba-PWV）作为动脉僵硬度的标志（49名男性和83名女性，70.3 ± 9.0岁）。分别在41例（31.0%）和53例（40.2%）受试者中观察到PVH和DWML。有PVH的受试者的ba-PWV值显著大于无PVH的受试者。DWML也倾向于与ba-PWV相关，但相关性无统计学意义。多因素Logistic回归分析显示年龄和舒张压下降与PVH独立相关。ba-PWV也被检测为PVH出现的独立因素（校正比值比：2.84，p=0.015），但不是DWML。这些结果表明，动脉硬度的增加有助于PVH的发病机制，而不是DWML。虽然需要进一步的研究来澄清WML亚型之间的差异，我们的研究表明，ba-PWV的测量是一个简单而有用的工具来检测脑动脉功能障碍。
The presence of cerebral white matter lesions (WMLs) on MRI is suggested to be a predictive factor for vascular dementia and stroke. To investigate the relationship between arterial stiffness and WMLs, we performed brain MRI to evaluate the presence of two subtypes of WML-periventricular hyperintensities (PVH) and deep white matter lesions (DWML)-and furthermore, determined the brachial-ankle pulse wave velocity (ba-PWV) as a marker of arterial stiffness in 132 elderly asymptomatic subjects (49 men and 83 women, 70.3 +/- 9.0 years). PVH and DWML were observed in 41 (31.0%) and 53 (40.2%) subjects, respectively. The ba-PWV values were significantly greater in subjects with PVH than in those without. DWML also tended to be associated with ba-PWV, but the correlation was not statistically significant. In multiple logistic regression analysis, age and decreased DBP were independently associated with PVH. ba-PWV was also detected as an independent factor for the appearance of PVH (adjusted odds ratio: 2.84, p=0.015) but not DWML. These results indicate that the increase in arterial stiffness contributes to the pathogenesis of PVH rather than DWML. Although further study is needed to clarify the difference between WML subtypes, our study suggests that the measurement of ba-PWV is a simple and useful tool for detecting cerebral arterial dysfunction.