Relating Function to Branching Geometry: A Micro-CT Study of the Hepatic Artery, Portal Vein, and Biliary Tree
Relating Function to Branching Geometry: A Micro-CT Study of the Hepatic Artery, Portal Vein, and Biliary Tree
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DOI：
10.1159/000323482
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Ritman, Erik L.
中科院分区：
文献类型：
--
作者：
Kline, Timothy L.;Zamir, Mair;Ritman, Erik L.
利用显微计算机断层扫描图像，对完整的大鼠肝叶的一条肝动脉、一条门静脉和两棵胆管树的层次结构、分支间节段长度和直径进行了表征。通过分析血管结构的几何特性，如分支间节段直径在分叉点处的变化，对数据进行了分析。对于肝动脉和门静脉树(与胆道树相比，其流速较高)，血管几何形状与旨在同时最小化层流功率损失的流体传输系统以及与维持系统所需的总材料体积(管腔内容物)成比例的成本函数是一致的。相比之下，胆管树(与肝动脉和门静脉的流量低，流向相反)被发现具有在分叉处维持管腔横截面积的几何形状。这些发现表明胆管树血管的组织结构和病理生理学可能与体动脉树内的血管有很大不同。通过在理论树模型中模拟这种误差并将结果与测量数据进行比较，检查了数据中的特征可变性/散布可能由成像和/或测量误差引起的程度。版权所有(C)2011 S.Karger AG，巴塞尔
Utilizing micro-computed tomography images, the hierarchical structure, interbranch segment lengths and diameters of a hepatic artery, a portal vein, and two biliary trees from intact rat liver lobes were characterized. The data were investigated by analyzing the geometric properties of the vascular structures, such as how interbranch segment diameters change at bifurcation points. In the case of the hepatic artery and portal vein trees (in which the flow rate is high by comparison with that in the biliary tree), the vascular geometry is consistent with a fluid transport system which aims to simultaneously minimize both the power loss of laminar flow, and a cost function proportional to the total volume of material needed to maintain the system (lumenal contents). In comparison, the biliary tree (which has a low flow rate and an opposite flow direction to that of the hepatic artery and portal vein) was found to have a geometry in which the lumen cross-sectional area is maintained at bifurcations. These findings imply that the histological makeup and therefore the pathophysiology of biliary tree vasculature are likely very different from that of the vasculature within the systemic arterial tree. The extent to which the characteristic variability/scatter in the data may have resulted from imaging and/or measurement errors was examined by simulating such errors in a theoretical tree model and comparing the results with the measured data. Copyright (C) 2011 S. Karger AG, Basel