When the Fight against Fungi Goes Wrong.
When the Fight against Fungi Goes Wrong.
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当对抗真菌的斗争出现问题时
DOI：
10.1371/journal.ppat.1005400
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发表时间：
2016-02
期刊：
影响因子：
6.7
通讯作者：
van de Veerdonk FL
中科院分区：
文献类型：
--
作者：
Wang X;van de Veerdonk FL
真菌与人类广泛的疾病有关，发病率和死亡率不断增加[1]。因此，阐明真菌感染易感性的遗传和免疫学机制具有重要意义。原发性免疫缺陷（PID）-一组遗传性免疫疾病，感染的易感性增加-最近的研究导致了重大突破，我们的细胞和分子机制，易患侵袭性和皮肤粘膜真菌感染的理解。这些知识将为在不久的将来开发新的免疫策略铺平道路。
Fungi are associated with a wide spectrum of diseases in humans, with increasing morbidity and mortality [1]. Therefore, it is of great importance to elucidate the genetic and immunological mechanisms underlying the susceptibility to fungal infections. Recent studies of primary immunodeficiencies (PIDs)—a group of hereditary immune disorders with increased susceptibility to infection—have led to significant breakthroughs in our understanding of cellular and molecular mechanisms that predispose to both invasive and mucocutaneous fungal infections. This knowledge will pave the way for developing novel immunotherapeutic strategies in the near future.