Sickle cell disease: management options and challenges in developing countries.
Sickle cell disease: management options and challenges in developing countries.
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DOI：
10.4084/mjhid.2013.062
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发表时间：
2013
影响因子：
3.2
通讯作者：
Ohene-Frempong K
中科院分区：
文献类型：
--
作者：
Ansong D;Akoto AO;Ocloo D;Ohene-Frempong K
镰状细胞病（SCD）是撒哈拉以南非洲地区最常见的血红蛋白遗传性疾病。这篇评论的重点是可用的管理方案和挑战，卫生保健专业人员在发展中国家面临的照顾与SCD患者。在加纳这样的发展中国家，新生儿筛查现在即将在全国范围内实施。与SCD相关的常见和重要的发病率是血管闭塞发作、感染、急性胸部综合征（ACS）、中风和髋关节坏死。发达国家对这些疾病的管理方法非常先进。发展中国家的环境差异和资源限制带来了挑战，对发展中国家的管理选择产生了重大影响。显然，发展中国家的临床医生在管理SCD患者方面面临挑战。然而，了解疾病，其进展，并制定适当的预防方法是至关重要的，在其管理。重点应放在早期咨询、新生儿筛查、抗微生物预防、预防感染的疫苗接种以及对保健工作者、病人和护理人员的培训。这些干预措施在发展中国家是负担得起的。
Sickle Cell Disease (SCD) is the most common genetic disorder of haemoglobin in sub-Saharan Africa. This commentary focuses on the management options available and the challenges that health care professionals in developing countries face in caring for patients with SCD. In a developing countries like Ghana, new-born screening is now about to be implemented on a national scale. Common and important morbidities associated with SCD are vaso-occlusive episodes, infections, Acute Chest Syndrome (ACS), Stroke and hip necrosis. Approaches to the management of these morbidities are far advanced in the developed countries. The differences in setting and resource limitations in developing countries bring challenges that have a major influence in management options in developing countries. Obviously clinicians in developing countries face challenges in managing SCD patients. However understanding the disease, its progression, and instituting the appropriate preventive methods are paramount in its management. Emphasis should be placed on early counselling, new-born screening, anti-microbial prophylaxis, vaccination against infections, and training of healthcare workers, patients and caregivers. These interventions are affordable in developing countries.