Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry.
Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry.
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DOI：
10.2337/dc12-0904
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发表时间：
2013-03
期刊：
影响因子：
16.2
通讯作者：
Kitazono T
中科院分区：
文献类型：
--
作者：
Ohkuma T;Fujii H;Iwase M;Kikuchi Y;Ogata S;Idewaki Y;Ide H;Doi Y;Hirakawa Y;Nakamura U;Kitazono T
目前关于睡眠时间对糖尿病患者血糖控制影响的研究很少。本研究的目的是研究2型糖尿病患者睡眠时间、肥胖和血糖水平之间的关系。将4870例年龄≥20岁的日本2型糖尿病患者根据自述睡眠时间分为小于4.5 h、4.5 - 5.4 h、5.5-6.4 h、6.5-7.4 h、7.5-8.4 h和大于8.5 h 6组。采用横断面方法研究睡眠时间与肥胖和HbA1c水平的关系。HbA1c水平与睡眠时间呈二次相关；也就是说，与6.5-7.4小时的睡眠时间相比，较短或较长的睡眠时间与较高的水平相关（P为二次趋势<0.001）。在调整了潜在的混杂因素（包括总能量摄入和抑郁症状）后，这种关联仍然显著。此外，肥胖的额外调整也显示出与睡眠时间的u型关系，并没有减弱u型睡眠-糖化血红蛋白的关联。观察到睡眠时间与年龄或胰岛素使用之间对HbA1c水平有显著的相互作用。研究显示，睡眠时间与2型糖尿病患者的肥胖和HbA1c水平呈u型相关，独立于潜在的混杂因素，因此可能是2型糖尿病患者临床管理的一个重要可修改因素。
Few studies are currently available regarding the influence of sleep duration on glycemic control in diabetic patients. The objective of the current study was to examine the relationship between sleep duration, obesity, and the glycemic level in type 2 diabetic patients. A total of 4,870 Japanese type 2 diabetic patients aged ≥20 years were divided into six groups according to their self-reported sleep duration: less than 4.5 h, 4.5–5.4 h, 5.5–6.4 h, 6.5–7.4 h, 7.5–8.4 h, and more than 8.5 h. The associations of sleep duration with obesity and the HbA1c levels were examined in a cross-sectional manner. The HbA1c levels showed a quadratic association with sleep duration; namely, a shorter or longer sleep duration was associated with a higher level compared with a sleep duration of 6.5–7.4 h (P for quadratic trend <0.001). This association remained significant after adjusting for potential confounders, including the total energy intake and depressive symptoms. Furthermore, additional adjustments for obesity, which also showed a U-shaped relationship with sleep duration, did not attenuate the U-shaped sleep-HbA1c association. A significant interaction between sleep duration and age or the use of insulin was observed for the HbA1c levels. Sleep duration was shown to have U-shaped associations with obesity and the HbA1c levels in type 2 diabetic patients, independent of potential confounders, and therefore may be an important modifiable factor for the clinical management of patients with type 2 diabetes.