Cortical event-related potentials in preclinical familial Alzheimer disease
Cortical event-related potentials in preclinical familial Alzheimer disease
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DOI：
10.1212/wnl.0b013e3181c1de77
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发表时间：
2009-11-17
期刊：
影响因子：
9.9
通讯作者：
Starr, A.
中科院分区：
文献类型：
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作者：
Golob, E. J.;Ringman, J. M.;Starr, A.
目的：明确家族性阿尔茨海默病(FAD)基因突变携带者在认知功能衰退开始前的皮质功能变化。方法：将26例有FAD家族史的受试者按基因分型分为2个亚组：FAD突变携带者15例，FAD非携带者11例。受试者接受标准化的认知功能测试和临床痴呆症评定量表(CDR)。在听觉辨别任务中记录感觉(P50，N100，P200)和认知(N200，P300)事件相关电位。结果：FAD基因突变携带者与非携带者在年龄和认知功能方面无明显差异，但FAD基因携带者CDR评分0.5分的发生率较高(1/10非携带者，5/15携带者)。与非携带者相比，FAD突变携带者的N100、P200、N200和P300成分潜伏期明显延长，慢波波幅较小。CDR评分为0.0的受试者的次级分析也显示FAD突变携带者潜伏期延长。结论：家族性阿尔茨海默病(FAD)突变患者的听觉感觉和认知皮质电位异常，大约在痴呆出现前10年。较长的事件相关潜在潜伏期表明FAD突变携带者的皮质信息处理速度减慢。神经病学(R)2009；73：1649-1655
Objective: To define changes in cortical function in persons inheriting familial Alzheimer disease (FAD) mutations before the onset of cognitive decline.Methods: Twenty-six subjects with a family history of FAD were divided into 2 subgroups according to genotype (FAD mutation carriers, n = 15; FAD noncarriers, n = 11). Subjects were given standardized tests of cognitive function and the Clinical Dementia Rating scale (CDR). Sensory (P50, N100, P200) and cognitive (N200, P300) event-related potentials were recorded during an auditory discrimination task. Amplitudes and latencies of cortical potentials were compared among FAD mutation carriers and noncarriers.Results: FAD mutation carriers and noncarriers did not significantly differ in age or on measures of cognitive function, but FAD carriers had a greater incidence of 0.5 CDR scores (1/10 noncarriers, 5/15 carriers). Relative to noncarriers, FAD mutation carriers had significantly longer latencies of the N100, P200, N200, and P300 components, and smaller slow wave amplitudes. Subanalyses of subjects having CDR scores of 0.0 also showed latency increases in FAD mutation carriers.Conclusions: Auditory sensory and cognitive cortical potentials in persons with familial Alzheimer disease (FAD) mutations are abnormal approximately 10 years before dementia will be manifest. Longer event-related potential latencies suggest slowing of cortical information processing in FAD mutation carriers. Neurology (R) 2009; 73: 1649-1655