Breast cancer imaging studies with a variable field of view PET cameral
Breast cancer imaging studies with a variable field of view PET cameral
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DOI：
10.1109/23.856550
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发表时间：
2000-06-01
影响因子：
1.8
通讯作者：
Wang, Y
中科院分区：
文献类型：
--
作者：
Baghaei, H;Wong, WH;Wang, Y
本文研究了德克萨斯大学MD安德森癌症中心（MDAPET）研制的原型高分辨率多环可变视野PET扫描仪的FDG乳腺生涯成像能力。分别采集热损伤幻影和暖背景的数据。然后，在图像重建之前，选择性地组合两组数据以生成所需SUV的数据。病灶直径和高度为3-6 mm，标准摄取值（SUV）为2.3 ~ 15。腋窝病灶成像试验中，将4个小的热病灶模型贴在躯干体模的腋窝区域，采用全身模式进行成像。为了创建逼真的背景，还对注射了3.5 mCi FDG的68 kg志愿者进行了成像。选择性地组合两组数据以生成所需SUV的正弦图数据。病灶直径4 ~ 11.5 mm，SUV范围2.5 ~ 17。原发病灶的影像学结果显示，当SUV> 2.5时，小（phi=11.5 cm）和大（phi 16 cm）乳房假体均可检出3 mm病灶。在全身模式下，病灶SUV为5或更高时，可检测到6 mm的腋窝病灶。
This is a study of the FDG breast career imaging capability of the prototype high resolution multi-ring variable field of view PET scanner developed at the University of Texas MD Anderson Cancer Center (MDAPET).For the primary-lesion-imaging test, four small phantom lesions embedded into two different size cylindrical breast phantoms were imaged using the breast-mode of the camera. Data for the hot lesion phantoms and the warm background were taken separately. Then, before image reconstruction, two sets of data were selectively combined to generate the data for the desired SUV. The cylindrical lesions have diameter and height of 3-6 mm with standard uptake value (SUV) ranging from 2.3 to 15.For the axillary-lesion imaging test, four small hot lesion phantoms taped to the axillary area of a torso phantom were imaged using a whole-body mode of the camera. To create a realistic background a 68-kg volunteer injected with 3.5 mCi of FDG were also imaged. The two sets of data were selectively combined to generate the sinogram data for the desired SUV. The lesions were 4-11.5 mm with SUV ranging from 2.5 to 17.The primary breast lesion imaging results show that a 3 mm lesion can be detected in both the small (phi=11.5 cm) and large (phi 16 cm) breast phantoms when SUV is greater than 2.5. In the whole body mode, axillary lesions of 6 mm can be detected for lesion SUV of 5 or more.