Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis
Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis
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DOI：
10.1086/315897
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发表时间：
2000-11-01
影响因子：
6.4
通讯作者：
Osame, M
中科院分区：
文献类型：
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作者：
Furukawa, Y;Yamashita, M;Osame, M
为研究人类T细胞嗜淋巴细胞病毒（HTLV）Ⅰ型tax变异与疾病转归的关系，测定了61例HTLV Ⅰ型相关性脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）、55例成人T细胞白血病和62例健康携带者（HC）的tax基因序列，系统发育分析显示，2个tax基因亚群的基础上的长末端重复序列相关。进一步分析192例HAM/TSP和200例HC患者的限制性片段长度多态性，发现HAM/TSP中1个tax亚组（taxA）的发生率较高。192例HAM/TSP患者中30例（15.5%）和200例HC中14例（7%）存在taxA。差异具有显著性（卡方检验（2）= 6.47; P = 0.014;比值比，2.46; 95%置信区间，1.26-4.80）。这种作用与HLA-A*02无关，据报道HLA-A*02可防止HAM/TSP的发展。这些结果表明，宿主遗传因素和HTLV-I亚群与HAM/TSP的发展风险不同。
The association between human T cell lymphotropic virus (HTLV) type I tax variation and disease outcome was studied, The tax gene was sequenced in 61 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 55 patients with adult T cell leukemia, and 62 healthy carriers (HCs), Phylogenetic analysis revealed 2 tax gene subgroups that are related on the basis of the long terminal repeat sequence. Further analysis using restriction fragment length polymorphism in 192 patients with HAM/TSP and 200 HCs revealed a higher incidence of 1 tax subgroup (taxA) in HAM/TSP. taxA was present in 30 (15.5%) of 192 patients with HAM/TSP and in 14 (7%) of 200 HCs. The difference was significant (chi (2) = 6.47; P = .014; odds ratio, 2.46; 95% confidence interval, 1.26-4.80). This effect was independent of HLA-A*02, which has been reported to prevent HAM/TSP development. These findings suggest that both host genetic factors and HTLV-I subgroup are associated with different risks for development of HAM/TSP.