Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
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DOI：
10.1016/s0140-6736(96)03173-x
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发表时间：
1996-07-20
期刊：
影响因子：
168.9
通讯作者：
Considine, RV
中科院分区：
文献类型：
--
作者：
Caro, JF;Kolaczynski, JW;Considine, RV
背景瘦素受体已从脉络丛中克隆，脉络丛是脑脊液（CSF）产生的部位，也是血液/脑脊液屏障的位置。因此，该受体可能作为瘦素的转运蛋白。我们研究了血清和脑脊液中瘦素的含量。方法和结果我们用放射免疫法和蛋白质印迹法证实了瘦素在人脑脊液中的存在。然后，我们测量了瘦素在CSF和血清中的31个个体与广泛的体重。8名肥胖者的平均血清瘦素水平（40.2 [SE 8.6] ng/mL）比23名消瘦者（9.6 [1.5] ng/mL，p
Background A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid (CSF) production and the location of the blood/cerebrospinal-fluid barrier. Thus, this receptor might serve as a transporter for leptin. We have studied leptin concentrations in serum and (CSF).Methods and findings We demonstrated by radioimmunoassay and western blot the presence of leptin in human CSF. We then measured leptin in CSF and serum in 31 individuals with a wide range of bodyweight. Mean serum leptin was 318% higher in 8 obese (40.2 [SE 8.6] ng/mL) than in 23 lean individuals (9.6 [1.5] ng/mL, p