Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
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DOI：
10.1038/s42003-018-0020-z
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发表时间：
2018
影响因子：
5.9
通讯作者：
Morohashi KI
中科院分区：
文献类型：
--
作者：
Baba T;Otake H;Inoue M;Sato T;Ishihara Y;Moon JY;Tsuchiya M;Miyabayashi K;Ogawa H;Shima Y;Wang L;Sato R;Yamazaki T;Suyama M;Nomura M;Choi MH;Ohkawa Y;Morohashi KI
管家代谢途径，如糖酵解，在所有类型的细胞中都是活跃的。此外，许多类型的细胞都配备了细胞特有的代谢途径。为了正确地履行它们的功能，管家和细胞特有的代谢途径必须协同工作。然而，结合代谢途径的调节机制在很大程度上仍不清楚。最近，我们发现调节类固醇合成基因的类固醇细胞特异性核受体Ad4BP/SF-1也调节管家糖酵解基因。在这里，我们确定了致胆固醇基因作为Ad4BP/SF-1的靶点。此外，我们发现Ad4BP/SF-1调控HUMR，HUMR是胆固醇从内质网运输到线粒体的候选中介。鉴于胆固醇是类固醇合成的起始物质，并由部分来源于葡萄糖的乙酰辅酶A合成，我们的结果表明参与合成类固醇激素的多个生物学过程受Ad4BP/SF-1调控。据我们所知，这项研究提供了第一个在转录水平上协调家务和细胞特定代谢的例子。Takashi Baba及其同事表明，类固醇生成细胞特异性核受体Ad4BP/SF-1针对的是胆固醇生成基因。鉴于胆固醇是类固醇激素的前体，这项研究表明Ad4BP/SF-1调节胆固醇的合成以促进类固醇的产生。
Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level. Takashi Baba and colleagues show that the steroidogenic cell-specific nuclear receptor Ad4BP/SF-1 targets cholesterogenic genes. Given that cholesterol is a precursor of the steroid hormones, this study suggests that Ad4BP/SF-1 regulates the synthesis of cholesterol to boost the production of steroids.
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DOI：
10.1016/s0960-0760(98)00062-4
发表时间：
1998-09-01
影响因子：
4.1
作者：
Cheng, B;Chou, SC;Kowal, J
通讯作者：
Kowal, J
影响因子：
4.8
作者：
Lopez, D;Sandhoff, TW;McLean, MP
通讯作者：
McLean, MP
影响因子：
6.5
作者：
Bochem, Andrea E.;Holleboom, Adriaan G.;Stroes, Erik S. G.
通讯作者：
Stroes, Erik S. G.
DOI：
10.1073/pnas.96.20.11041
发表时间：
1999-09-28
影响因子：
11.1
作者：
Brown, MS;Goldstein, JL
通讯作者：
Goldstein, JL
影响因子：
29
作者：
Kennedy, MA;Barrera, GC;Edwards, PA
通讯作者：
Edwards, PA