Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats.
Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats.
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DOI：
10.1089/jmf.2000.3.141
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发表时间：
2000-01-01
影响因子：
2.4
通讯作者：
Wilson, T
中科院分区：
文献类型：
--
作者：
Maher, M A;Mataczynski, H;Wilson, T
红酒能使大鼠主动脉血管扩张，这是一种多酚类化合物的作用。蔓越莓汁（CBJ）也富含多酚。我们确定CBJ具有与红酒相似的血管放松特性。用Krebs缓冲液清洗大鼠主动脉环，pH为7.4,95% O(2)和5% CO(2)起泡，37℃，2.0 g张力下恢复30分钟。在苯肾上腺素（PE, 100 μ mol/L）收缩后，乙酰胆碱（3 μ mol/L）诱导的完整血管舒张率显著高于剥离血管（59.1 +/- 0.27% vs 10.1 +/- 0.09%）
ABSTRACT Red wine vasodilates rat aortae, an effect attributed to polyphenolic compounds. Cranberry juice (CBJ) is also rich in polyphenols. We determined that CBJ has vasorelaxing properties similar to those of red wine. Rat aortic rings cleaned in Krebs buffer, pH 7.4, bubbled with 95% O(2) and 5% CO(2) were recovered for 30 minutes at 37 degrees C under 2.0 g tension. After phenylephrine (PE, 100 mumol/L) contraction, acetylcholine (3 mumol/L)-induced relaxation of intact vessel was significantly higher than in denuded vessels (59.1 +/- 0.27% versus 10.1 +/- 0.09% of the maximal PE contraction; P