miRDB: A microRNA target prediction and functional annotation database with a wiki interface
miRDB: A microRNA target prediction and functional annotation database with a wiki interface
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DOI：
10.1261/rna.965408
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发表时间：
2008-06-01
期刊：
影响因子：
4.5
通讯作者：
Wang, Xiaowei
中科院分区：
文献类型：
--
作者：
Wang, Xiaowei
microRNA（miRNAs）是一类短的非编码RNA，参与调控数千个基因靶点。最近的研究表明，miRNAs可能是许多重要生物过程的主要调节因子。由于其功能的重要性，目前对miRNA的研究非常深入，近年来发表了许多关于miRNA功能特性的研究。miRNA知识的快速积累使得正确组织和呈现miRNA功能数据具有挑战性。尽管最近已经开发了一些miRNA功能数据库，但这仍然是miRNA研究界面临的主要生物信息学挑战。在这里，我们描述了一个新的在线数据库系统，miRDB，在miRNA靶点预测和功能注释。开发了灵活的Web搜索界面，用于检索目标预测结果，这些结果是用我们最近开发的新的生物信息学算法生成的。与大多数其他miRNA数据库不同，miRDB中的miRNA功能注释主要集中在成熟的miRNA上，成熟的miRNA是miRNA介导的基因表达调控的功能载体。此外，还建立了一个wiki编辑界面，允许任何可以访问Internet的人对miRNA功能注释做出贡献。这是一个新的尝试，开发一个互动的社区注释的miRNA功能目录。存储在miRDB中的所有数据都可以在http://mirdb.org上免费访问。
MicroRNAs (miRNAs) are short noncoding RNAs that are involved in the regulation of thousands of gene targets. Recent studies indicate that miRNAs are likely to be master regulators of many important biological processes. Due to their functional importance, miRNAs are under intense study at present, and many studies have been published in recent years on miRNA functional characterization. The rapid accumulation of miRNA knowledge makes it challenging to properly organize and present miRNA function data. Although several miRNA functional databases have been developed recently, this remains a major bioinformatics challenge to miRNA research community. Here, we describe a new online database system, miRDB, on miRNA target prediction and functional annotation. Flexible web search interface was developed for the retrieval of target prediction results, which were generated with a new bioinformatics algorithm we developed recently. Unlike most other miRNA databases, miRNA functional annotations in miRDB are presented with a primary focus on mature miRNAs, which are the functional carriers of miRNA-mediated gene expression regulation. In addition, a wiki editing interface was established to allow anyone with Internet access to make contributions on miRNA functional annotation. This is a new attempt to develop an interactive community-annotated miRNA functional catalog. All data stored in miRDB are freely accessible at http://mirdb.org.