Chemokines and chemokine receptors: new insights into cancer-related inflammation.
Chemokines and chemokine receptors: new insights into cancer-related inflammation.
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DOI：
10.1016/j.molmed.2010.01.003
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发表时间：
2010-03
影响因子：
13.6
通讯作者：
Richmond A
中科院分区：
文献类型：
--
作者：
Lazennec G;Richmond A
在经常与炎症相关的情况下，趋化因子参与细胞的相互作用和趋向性。最近，趋化因子和趋化因子受体在与癌变相关的炎症中的重要性已经被强调。越来越多的证据表明，趋化因子由肿瘤细胞产生，也由肿瘤微环境中的细胞产生，包括肿瘤相关的成纤维细胞、间充质干细胞、内皮细胞、肿瘤相关的巨噬细胞以及最近的肿瘤相关的中性粒细胞。趋化因子除了对肿瘤细胞增殖、血管生成和转移有影响外，似乎还能调节衰老和细胞存活。本文就趋化因子和趋化因子受体在癌症相关炎症中作用的最新进展进行综述，并对趋化因子在癌症中的作用机制进行讨论，以期促进未来新疗法的发展。
Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells and also by cells of the tumor microenvironment including cancer-associated fibroblasts, mesenchymal stem cells, endothelial cells, tumor-associated macrophages and more recently tumor-associated neutrophils. In addition to having effects on tumor cell proliferation, angiogenesis and metastasis, chemokines also appear to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and we discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.
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影响因子：
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作者：
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通讯作者：
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作者：
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Bachelerie, F