Fine structure of the apical rim-mesenchyme complex during limb morphogenesis in man.
Fine structure of the apical rim-mesenchyme complex during limb morphogenesis in man.
复制标题
人类肢体形态发生过程中顶缘-间质复合体的精细结构。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
R. O. Kelley
中科院分区：
文献类型：
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作者：
R. O. Kelley
15-18天人的顶缘-基底板-间充质复合体的超微结构与肢体发育有关。1.根尖上皮是一种复杂的组织，表现为表面微绒毛、连接复合体、游离核糖体、精细高尔基中心、糖原和稀少的颗粒内质网。2.顶缘在第15和16期增厚，指尖端保持多层，第17和18期邻近坏死区变薄。上皮变薄可能是缺乏‘维持因子’的反应。3.在这些阶段中存在一个连续的基板。指间坏死区有大量胶原样纤维，指母细胞顶端稀疏。4.指间上皮中有定向微丝的存在，提示在人手指形态发生过程中存在主动内陷现象。
Ultrastructure of the apical rim–basal lamina–mesenchyme complex in man during Horizons 15–18 is correlated with the development of limbs. 1. Apical epithelium is a complicated tissue exhibiting surface microvilli, junctional complexes, free ribosomes, elaborate Golgi centers, glycogen and scanty granular endoplasmic reticulum. 2. The apical rim thickens during stages 15 and 16, remaining multilayered at digital tips and thinning adjacent to zones of necrosis by stages 17 and 18. Epithelial thinning may be a response to lack of ‘maintenance factor’. 3. A continuous basal lamina is present during these stages. Collagen-like fibrils are numerous in interdigital zones of necrosis and sparse at tips of digital blastemata. 4. The presence of oriented microfilaments in interdigital epithelium suggests active invagination during morphogenesis of fingers in man.