The biocompatibility, integrity, and positional stability of an injectable microstimulator for reanimation of the paralyzed larynx.
The biocompatibility, integrity, and positional stability of an injectable microstimulator for reanimation of the paralyzed larynx.
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用于恢复麻痹喉部的可注射微刺激器的生物相容性、完整性和位置稳定性。
DOI：
10.1109/10.936365
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Najafi,K
中科院分区：
文献类型：
--
作者：
Zealear,DL;Garren,KC;Rodriguez,RJ;Reyes,JH;Huang,S;Dokmeci,MR;Najafi,K
研究了密封可注射无线微机械微刺激器的生物相容性、完整性、位置稳定性和潜在用途，用于麻痹喉的复苏。该器械由硅和玻璃组成，经测试证明具有生物相容性，在大鼠背部和犬喉植入长达一年时，没有病理组织反应或排斥反应的证据。到一个月时，每个单元被薄膜包裹，该薄膜在6-12个月时增厚以形成小于500 /spl mu/m的纤维层。微刺激器表现出长期的体内耐久性：只有十分之一的器械的密封被破坏。植入后，器械的移位范围为0 - 3 cm，取决于手术剥离的程度。当组织夹层最小时，未观察到可辨别的移位。使用配备有电极的改良器械的研究表明，移位是标称的，具有足够的位置稳定性，以确保激活靶肌肉以打开声门。这项研究支持了使用微刺激器复苏麻痹喉肌以在呼吸过程中打开气道的可行性。这种创新的治疗方法将减轻气管切开术或声带手术切除的需要。
The biocompatibility, integrity, positional stability, and potential use of hermetically sealed injectable wireless micromachined microstimulators were investigated for reanimation of the paralyzed larynx. The device, consisting of silicon and glass, has been tested and proven to be biocompatible with no evidence of pathological tissue reaction or rejection up to one-year implantation in the rat dorsum and canine larynx. By one month, each unit was encapsulated by a thin membrane, which thickened to form a fibrous layer of less than 500 /spl mu/m at 6-12 months. The microstimulators demonstrated long-term in vivo durability: the hermetic seal of only one in ten devices was breached. Once implanted, migration of the device varied from 0 to 3 cm, depending upon the extent of surgical dissection. No discernable migration was noted when the tissue dissection was minimal. Studies utilizing a modified device equipped with electrodes indicated that migration was nominal with sufficient positional stability to ensure activation of target muscles for glottis opening. This study supported the feasibility of using a microstimulator for reanimation of paralyzed laryngeal muscles that open the airway during breathing. This innovative approach to treatment would alleviate the need for a tracheotomy or surgical resection of the vocal fold.