Microbial sialidases: does bigger always mean better?
Microbial sialidases: does bigger always mean better?
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DOI：
10.1016/0966-842x(94)90003-5
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发表时间：
1994-08
影响因子：
15.9
通讯作者：
E. Vimr
中科院分区：
文献类型：
--
作者：
E. Vimr
唾液酸酶是n -酰基神经氨酸释放（唾液酸释放）外糖苷酶的一个超家族，主要存在于高等真核生物和一些主要致病的病毒、细菌和原生动物中。唾液酸酶的功能了解甚少，直到最近，它们的生化和进化关系还不清楚。一种比较方法已经证明了非病毒唾液酸酶之间的显著相似性和差异性，并为它们的功能提供了线索。
Sialidases are a superfamily ofN-acylneuraminate-releasing (sialic-acid-releasing) exoglycosidases found mainly in higher eukaryotes and in some, mostly pathogenic, viruses, bacteria and protozoans. The functions of sialidases are poorly understood and, until recently, their biochemical and evolutionary relationships were unclear. A comparative approach has demonstrated the remarkable similarities and differences between nonviral sialidases, and is providing clues about their functions.