Beclin 1 expression A predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type
Beclin 1 expression A predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type
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DOI：
10.4161/auto.6.6.12784
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发表时间：
2010-08-16
期刊：
影响因子：
13.3
通讯作者：
Li, Zhi-Ming
中科院分区：
文献类型：
--
作者：
Huang, Jia-Jia;Li, Hao-Ran;Li, Zhi-Ming
Beclin 1在自噬、分化、抗细胞凋亡和肿瘤的发生发展中起重要作用。Beclin 1在自然杀伤T细胞淋巴瘤中的功能和表达在很大程度上尚不清楚。本研究旨在探讨Beclin 1在结外自然杀伤T细胞淋巴瘤鼻型中的表达及其与预后的关系。应用免疫组织化学(IHC)法检测65例初诊ENKL患者肿瘤标本中Beclin-1蛋白的表达。统计分析Beclin-1在EKL中的临床意义。65例标本中有56例(86.2%)Beclin-1免疫阳性。Beclin 1低表达与Ann Arbor分期、中高度IPI风险和LDH水平升高显著相关。Beclin 1低表达与总生存期(OS；p=0.001)和无进展生存期(PFS；p=0.017)相关。多因素分析发现Beclin 1表达、Ann Arbor分期和B症状是影响OS和PFS预后的独立因素。因此，提出了一种新的临床病理预后模型。该模型可以根据OS和PFS区分低风险组和高风险组的不同生存结果(p<；0.0001)。Beclin 1表达可预测ENKL的预后。新的临床病理预后模型可能有助于识别不同临床结局的患者。
Beclin 1 plays an important role in autophagy, differentiation, antiapoptosis and the development and progression of cancer. The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored. The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal-type (ENKL). Beclin 1 protein expression in 65 tumor specimens from patients newly diagnosed with ENKL was examined by immunohistochemistry (IHC). The clinical significance of Beclin 1 in ENKL was statistically analyzed. Immunopositivity for Beclin 1 was found in 56 (86.2%) of the 65 samples. Low Beclin 1 expression was significantly associated with advanced Ann Arbor stage, intermediate to high IPI risk and elevated LDH level. Low Beclin 1 expression was associated with worse overall survival (OS; p = 0.001) and progression-free survival (PFS; p = 0.017). In multivariate analysis, Beclin 1 expression, advanced Ann Arbor stage and B symptoms were found to be independent prognostic factors of OS and PFS. Consequently, a new clinico-pathological prognostic model was proposed. The model could discriminate different survival outcomes between low risk and high risk groups based on OS and PFS (p < 0.0001, respectively). Beclin 1 expression is predictive of prognosis in ENKL. The new clinico-pathological prognostic model may be help identify patients with different clinical outcomes.