Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment
Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment
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DOI：
10.1038/ajg.2009.642
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发表时间：
2010-03-01
影响因子：
9.8
通讯作者：
Cavallo, Luciano
中科院分区：
文献类型：
--
作者：
Delvecchio, Maurizio;De Bellis, Annamaria;Cavallo, Luciano
目的：腹腔疾病（CD）患者脑垂体可能存在自身免疫性受累，但仅在少数无麸质饮食患者中得到证实。我们的目的是评估抗垂体抗体（阿帕）的患病率和临床意义的儿童和青少年与新诊断的CD。方法：共119例CD患者（0.9-15.8岁）参加了大学医院的住院门诊的横断面研究。记录身高、体重、体重指数（BMI），测定胰岛素样生长因子-1（IGF-1）和阿帕。结果：50例患者（42.0%）检出阿帕，其中高滴度15例（30%），低滴度35例（70%），2例正常对照者（2%）检出APA（P
OBJECTIVES: The possible autoimmune involvement of the pituitary gland in patients with celiac disease (CD) has been suggested but demonstrated in only a few patients on gluten-free diet. We aimed to assess the prevalence and clinical meaning of anti-pituitary antibodies (APA) in children and adolescents with the newly diagnosed CD.METHODS: A total of 119 patients with CD (0.9-15.8 years old) attending the inpatient clinic of University Hospital were recruited for the cross-sectional study. Their height, weight, and body mass index (BMI) were recorded, and insulin-like growth factor-1 (IGF-1) and APA were assayed. APA was also determined in 98 sex-and age-matched controls.RESULTS: APA were detected in 50 patients (42.0%), 15 of them with high titer (30%) and 35 with low titer (70%), and in 2 control subjects at low titer (2%) (P