Sleep in Autism
Sleep in Autism
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DOI：
10.1055/s-0037-1604353
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发表时间：
2017-08-01
影响因子：
2.7
通讯作者：
Malow, Beth A.
中科院分区：
文献类型：
--
作者：
Maxwell-Horn, Angela;Malow, Beth A.
自闭症谱系障碍（ASD）是一种神经发育障碍，在过去的几十年里患病率有所上升。很大比例的ASD患儿同时伴有睡眠障碍。ASD和睡眠之间的相互作用是多因素和双向的。有证据表明，ASD的生理差异会导致睡眠问题，包括感觉过度反应（SOR）和褪黑激素分泌异常。与ASD相关的合并症（注意缺陷多动障碍[ADHD]，情绪障碍）以及用于治疗这些合并症的药物通常会影响睡眠结构。在这篇文章中，作者讨论了ASD儿童睡眠障碍的病因和表现，以及他们的临床评估和治疗方案。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has increased in prevalence over the last several decades. A significant proportion of children with ASD have comorbid sleep disorders. The interplay between ASD and sleep is multifactorial and bidirectional. There is evidence for physiological differences in ASD that contribute to sleep problems, including sensory overresponsiveness (SOR) and abnormal melatonin production. Comorbidities associated with ASD (attention deficit hyperactivity disorder [ADHD], mood disorders) as well as medications used to treat these comorbidities often have effects on sleep architecture. In this article the authors discuss the etiology and manifestations of sleep disorders in children with ASD, as well as their clinical evaluation and treatment options.