Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation
Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation
复制标题
手性超分子配位笼作为β淀粉样蛋白聚集的高性能抑制剂
DOI：
10.1039/c8cc04913k
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发表时间：
2018-08-14
影响因子：
4.9
通讯作者：
Gu, Zhi-Guo
中科院分区：
文献类型：
--
作者：
Bao, Ling-Yu;Hao, Si-Jia;Gu, Zhi-Guo
4对手性超分子配位笼可以有效抑制淀粉样蛋白- β (A β)的聚集，抑制率为0.64-0.86。本研究为利用超分子金属-有机笼设计手性a β抑制剂提供了新的视角。
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-beta (A beta) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral A beta inhibitors using supramolecular metal-organic cages.