Quantitative Optical Coherence Elastography of the Optic Nerve Head In Vivo.
Quantitative Optical Coherence Elastography of the Optic Nerve Head In Vivo.
复制标题
体内视神经头的定量光学相干弹性成像。
DOI：
10.1109/tbme.2023.3316606
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Chen,Zhongping
中科院分区：
文献类型：
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作者：
Zhang,Fengyi;Li,Runze;Li,Yan;Zhu,Zhikai;Zhou,Qifa;Chen,Zhongping
方法应用光学相干弹性成像系统（Optical Coherence Elastography，OCE）对离体和在体兔视神经乳头（optic nerve head，ONH）进行成像，观察ONH弹性与不同眼压水平的关系。机械振动器启动弹性波的传播，并且通过跟踪波的传播速度来确定ONH的弹性。基于波速重建不同IOP水平下ONH的弹性。值得注意的是，ONH表现出增加的刚度与升高的IOP.ResultsIn在体内兔模型中，ONH的杨氏模量从14 kPa增加到81 kPa与IOP从15 mmHg增加到35 mmHg。这揭示了ONH的杨氏模量与眼内压之间的正相关性。结论OCE系统被证明是有效的，在测量ONH的机械性能在不同的IOP水平，在体内兔模型的验证。成像和量化体内ONH生物力学性质的能力对于推进视觉科学研究和改善青光眼患者的临床管理具有巨大潜力。
ObjectiveOptical coherence elastography (OCE) was used to demonstrate the relationship between the elasticity of the optic nerve head (ONH) and different intraocular pressure (IOP) levels in an in-vivo rabbit model for the first time.MethodBoth ex-vivo and in-vivo rabbit ONH were imaged using OCE system. A mechanical shaker initiated the propagation of elastic waves, and the elasticity of the ONH was determined by tracking the wave propagation speed. The elasticity of the ONH under varying IOP levels was reconstructed based on the wave speed. Notably, the ONH exhibited increased stiffness with elevated IOP.ResultsIn the in-vivo rabbit models, the Young's modulus of ONH increased from 14 kPa to 81 kPa with the IOP increased from 15 mmHg to 35 mmHg. This revealed a positive correlation between the Young's modulus of the ONH and intraocular pressure.ConclusionThe OCE system proved effective in measuring the mechanical properties of ONH at different IOP levels, with validation in an in-vivo rabbit model.SignificanceConsidering ONH plays a critical role in vision and eye diseases, the capability to image and quantify in vivo ONH biomechanical properties has great potential to advance vision science research and improve the clinical management of glaucoma patients.