Space-rate coding in an adaptive silicon neuron
Space-rate coding in an adaptive silicon neuron
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DOI：
10.1016/s0893-6080(01)00082-x
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发表时间：
2001-07
期刊：
影响因子：
--
通讯作者：
Kai M. Hynna;K. Boahen
中科院分区：
文献类型：
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作者：
Kai M. Hynna;K. Boahen
神经生理学主要是在受控条件下研究单个神经元的尖峰速率，希望这些结果反映神经元群体的计算方式。然而，如果膜电压的变化率在接近尖峰放电阈值时急剧下降，则群体响应与单神经元响应完全不同。通过延迟尖峰发放，这种转换速率适应已被证明可以调节尖峰发放速率并延长单神经元水平的突触整合。我们在这里展示了它在群体水平上提高了灵敏度并缩短了潜伏期。因此，转换速率自适应使神经元能够通过使用空间速率编码而不是时间速率编码来比它们的峰间间隔更快地处理信息。这项研究还表明，神经种群如何通过调节主动电导来调节它们的增益和同步性。我们的研究结果是外推从一个单一的硅神经元，钙和电压依赖性钾通道类似物进行的实验和分析。
Neurophysiology is largely the study of spike rates of single neurons, under controlled conditions, with the hope that these results reflect how populations of neurons compute. However, the population response differs radically from the single-neuron response if the membrane voltage's rate of change drops dramatically when it is close to the spike-firing threshold. By delaying spiking, this slew-rate adaptation has been shown to regulate spike rate and prolong synaptic integration at the single-neuron level. We show here that it sharpens sensitivity and shortens latency at the population level. Thus, slew-rate adaptation enables neurons to process information faster than their interspike interval by using space-rate coding, instead of time-rate coding. This study also suggests how neural populations can modulate their gain and synchrony by regulating active conductances. Our results are extrapolated from experiments and analysis performed on a single silicon neuron, with Ca- and voltage-dependent potassium-channel analogs.