STIMULATION OF AFFERENT NERVE-ENDINGS BY INTRAGASTRIC CAPSAICIN PROTECTS AGAINST ETHANOL-INDUCED DAMAGE OF GASTRIC-MUCOSA
STIMULATION OF AFFERENT NERVE-ENDINGS BY INTRAGASTRIC CAPSAICIN PROTECTS AGAINST ETHANOL-INDUCED DAMAGE OF GASTRIC-MUCOSA
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DOI：
10.1016/0306-4522(88)90201-1
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发表时间：
1988-12-01
期刊：
影响因子：
3.3
通讯作者：
LIPPE, IT
中科院分区：
文献类型：
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作者：
HOLZER, P;LIPPE, IT
辣椒素敏感性传入神经元的消融增强实验诱导的大鼠胃粘膜溃疡，这表明这些神经元参与胃粘膜保护。为了提供这种功能的直接证据，研究了通过胃内给予辣椒素刺激传入神经末梢是否可以抵消25%乙醇的致溃疡作用。辣椒素（3.2-640 μ M）与乙醇一起给药，以浓度依赖性方式抑制出血性病变的发展，但不改变乙醇诱导的胃电位差下降。这表明辣椒素不能阻止乙醇损伤胃上皮细胞，但可以抵消乙醇引起的血管病变。在成年大鼠中，胃内辣椒素的抗损伤作用是不存在的，所述成年大鼠在新生时用高剂量的全身性辣椒素处理，以实现无髓传入神经元的永久变性。因此，看来胃内辣椒素通过对传入神经元的作用减少损伤形成。急性迷走神经切断术，急性切除腹腔-肠系膜上神经节复合体，急性双侧肾上腺结扎，或用阿托品或乙啶预处理大鼠后，胃内辣椒素的保护作用没有改变。这些结果表明，辣椒素刺激传入神经元胃内提供保护大鼠胃粘膜对乙醇引起的损害。由于自主神经系统不参与，胃保护似乎代表胃中感觉神经末梢的局部效应器功能。
Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in gastric mucosal protection. To provide direct evidence for such a function it was investigated whether stimulation of afferent nerve endings by the intragastric administration of capsaicin could counteract the ulcerogenic effect of 25% ethanol. Capsaicin (3.2-640 .mu.M), administered together with ethanol, inhibited the development of haemorrhagic lesions in a concentration-dependent fashion but did not alter the ethanol-induced fall in the gastric potential difference. This suggests that capsaicin does not prevent ethanol from damaging gastric epithelial cells but can counteract the vascular lesions caused by ethanol. The anti-lesion effect of intragastric capsaicin was absent in adult rats which had bee n treated with a high dose of systemic capsaicin as neonates in order to achieve a permanent degeneration of unmyelinated afferent neurons. It would appear, therefore, that intragastric capsaicin reduces lesion formation by an action on afferent neurons. The protective effect of intragastric capsaicin was not altered following acute subdiaphragmatic vagotomy, acute removal of the coeliac-superior mesenteric ganglion complex, acute bilateral ligation of the adrenal glands, or pretreatment of the rats with atropine or guanethidine. These findings indicate that stimumlation of afferent neurons by intragastric capsaicin affords protection of the rat gastric mucosa against ethanol-induced damage. As the autonomic nervous system is not involved gastroprotection appears to represent a local effector function of sensory nerve endings in the stomach.