The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA.

The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA.
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使用 Affymetrix GeneChips 作为研究 RNA 替代形式的工具。

DOI:
10.1042/bst0360511
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发表时间:
2008
影响因子:
3.9
通讯作者:
Harrison AP
Harrison AP
中科院分区:
生物学3区
文献类型:
--
作者:
Harrison AP

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我们正在开发一个计算管道,以使用Affyscore基因芯片的调查作为发现工具,用于解开一些与RNA转录后加工相关的生物学。这项工作涉及到许多生物信息学资源的整合,从比较注释到处理图像,再到确定转录本的结构。快速增长的基因芯片数据集提供给社区,使我们处于一个强有力的地位,发现新的生物学关于转录后加工,并应使我们能够确定的机制,其中一些群体的基因使协调的变化,在其生产的异构体。
We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
DOI: 10.1186/1471-2105-8-13
发表时间: 2007-01-15
期刊: BMC BIOINFORMATICS
影响因子: 3
作者:
Stalteri, Maria A;Harrison, Andrew P
通讯作者: Harrison, Andrew P