Impact of caspase-8 (CASP8) -652 6N del and D302H polymorphisms on prostate cancer in different ethnic groups.
Impact of caspase-8 (CASP8) -652 6N del and D302H polymorphisms on prostate cancer in different ethnic groups.
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DOI：
10.7314/apjcp.2014.15.18.7713
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发表时间：
2014-10
期刊：
影响因子：
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通讯作者：
Chengdong Zhang;Hong-tao Li;Kun Liu;Zhidi Lin;Qi-liu Peng;Xue-Qian Qin;Min He;Hua Wu;Z. Mo;Xiao-Li Yang
中科院分区：
文献类型：
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作者：
Chengdong Zhang;Hong-tao Li;Kun Liu;Zhidi Lin;Qi-liu Peng;Xue-Qian Qin;Min He;Hua Wu;Z. Mo;Xiao-Li Yang
尽管有证据表明CASP8 -652 - 6N - del和D302H多态性在前列腺癌（PCa）中的作用，但这些多态性与PCa风险的关系仍不确定。因此，我们进行了一项荟萃分析，以更精确地估计CASP8 - 6526n del和D302H多态性与PCa易感性的关系。材料与方法对所有CASP8 D302H和- 6526n del多态性与PCa风险的病例对照研究进行了全面的文献检索。比值比（ORs）和95%置信区间（CIs）分别用于评估关联强度和估计精度。结果纳入9项-625 - 6N模型研究和4项D302H研究。在整体分析中，CASP8 -652 - 6N del和D302H多态性与PCa风险无显著相关。然而，在按种族分层的亚组分析中，在隐性模型下，- 6256n基因与东亚和印度人群的PCa风险显著相关。此外，亚组分析强烈表明，在显性模型下，D302H与非印度人群较低的PCa风险相关。结论：在我们的荟萃分析中，CASP8 - 6256n del和D302H多态性与PCa风险的相关性存在明显的种族特异性差异。
BACKGROUND Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphisms in prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore, a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302H polymorphisms with PCa susceptibility. MATERIALS AND METHODS A comprehensive literature search was conducted to identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision of the estimate, respectively. RESULTS Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6N del and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However, in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in the East Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis strongly suggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominant model. CONCLUSIONS In our meta-analysis, ethnic-specific differences were evident in the association of CASP8 -625 6N del and D302H polymorphisms with PCa risk.