The Menopausal Transition and Cardiovascular Risk
The Menopausal Transition and Cardiovascular Risk
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DOI：
10.1016/j.ogc.2011.05.005
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发表时间：
2011-09-01
影响因子：
3.2
通讯作者：
Derby, Carol A.
中科院分区：
文献类型：
--
作者：
Chae, Claudia U.;Derby, Carol A.
心血管疾病是妇女死亡的主要单一原因，在绝经后发病率大幅增加。这可能与绝经过渡期发生的心血管危险因素的不良变化有关。脂质和载脂蛋白谱的致动脉粥样硬化性变化似乎与卵巢衰老特别相关;其他心血管危险因素的不利变化可能更多地受到年龄老化的影响。无论这些变化是由于衰老还是更年期本身，在绝经前和绝经期增加对风险因素修改的关注将有助于降低女性未来的心血管疾病风险。
The incidence of cardiovascular disease, which is the leading single cause of death among women, increases substantially after menopause. This may be related to adverse changes in cardiovascular risk factors that occur during the menopausal transition. Proatherogenic changes in lipid and apolipoprotein profiles seem to be specifically related to ovarian aging; unfavorable changes in other cardiovascular risk factors may be influenced more by chronologic aging. Whether these changes are due to aging or to menopause itself, increased attention to risk factor modification in the pre- and perimenopausal years will help reduce future cardiovascular disease risk among women.