A mathematical analysis of the generation and termination of calcium sparks
A mathematical analysis of the generation and termination of calcium sparks
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DOI：
10.1016/s0006-3495(04)74203-4
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发表时间：
2004-03-01
影响因子：
3.4
通讯作者：
Hinch, R
中科院分区：
文献类型：
--
作者：
Hinch, R
钙火花是肌浆网上一簇兰尼碱受体的局部再生性钙释放。在心脏细胞的兴奋-收缩偶联过程中，Ca 2+火花由通过T-小管进入细胞的Ca 2+触发（Ca 2+诱导的Ca 2+释放）。然而，在钙超载的条件下，可以自发地触发Ca 2+火花。钙离子火花终止的确切过程仍然是一个悬而未决的问题，尽管确定性和随机性过程可能都很重要。在这篇文章中，渐近方法被用来分析一个单一的钙火花模型，其中包括确定性和随机生物物理机制。分析计算火花频率和火花持续时间分布，并显示在什么情况下随机过渡是重要的。此外，通过FK结合蛋白的释放通道的耦合模型进行了分析。
Calcium sparks are local regenerative releases of Ca2+ from a cluster of ryanodine receptors on the sarcoplasmic reticulum. During excitation-contraction coupling in cardiac cells, Ca2+ sparks are triggered by Ca2+ entering the cell via the T-tubules (Ca2+-induced Ca2+ release). However under conditions of calcium overload, Ca2+ sparks can be triggered spontaneously. The exact process by which Ca2+ sparks terminate is still an open question, although both deterministic and stochastic processes are likely to be important. In this article, asymptotic methods are used to analyze a single Ca2+ spark model, which includes both deterministic and stochastic biophysical mechanisms. The analysis calculates both spark frequencies and spark duration distributions, and shows under what circumstances stochastic transitions are important. Additionally, a model of the coupling of the release channels via the FK-binding protein is analyzed.