Wnt signalling underlies the evolution of new phenotypes and craniofacial variability in Lake Malawi cichlids.
Wnt signalling underlies the evolution of new phenotypes and craniofacial variability in Lake Malawi cichlids.
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Wnt 信号传导是马拉维湖慈鲷新表型和颅面变异进化的基础。
DOI：
10.1038/ncomms4629
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发表时间：
2014
影响因子：
16.6
通讯作者：
Albertson,RCraig
中科院分区：
文献类型：
--
作者：
Parsons,KevinJ;TrentTaylor,A;Powder,KaraE;Albertson,RCraig
就促进和限制进化的直接分子因素而言，在机制水平上理解适应性辐射的进展仍然有限。在这里，我们重点关注颅面骨骼，并表明个体发育早期扩展的 Wnt/β-catenin 信号传导与马拉维湖慈鲷的表型新颖性和生态机会的进化相关。我们证明，这种分子变化的作用方式是有效锁定早期幼虫表型，可能是通过加速骨沉积速率。然而，我们进一步证明，这种表型新颖性的变化可能反过来通过个体发育后期颅面可塑性的相应降低而限制进化潜力。总之，我们的数据表明 Wnt 通路是颅面形态的重要中介，并为发育系统如何进化以促进和限制进化变化提供了新的见解。
Progress towards understanding adaptive radiations at the mechanistic level is still limited with regard to the proximate molecular factors that both promote and constrain evolution. Here we focus on the craniofacial skeleton and show that expanded Wnt/β-catenin signalling early in ontogeny is associated with the evolution of phenotypic novelty and ecological opportunity in Lake Malawi cichlids. We demonstrate that the mode of action of this molecular change is to effectively lock into place an early larval phenotype, likely through accelerated rates of bone deposition. However, we demonstrate further that this change toward phenotypic novelty may in turn constrain evolutionary potential through the corresponding reduction in craniofacial plasticity at later stages of ontogeny. In all, our data implicate the Wnt pathway as an important mediator of craniofacial form and offer new insights into how developmental systems can evolve to both promote and constrain evolutionary change.