Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens
Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens
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DOI：
10.1097/jom.0000000000001106
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发表时间：
2017-11-01
影响因子：
3.2
通讯作者：
Hanke, Wojciech
中科院分区：
文献类型：
--
作者：
Jurewicz, Joanna;Radwan, Michal;Hanke, Wojciech
目的：本研究的目的是评估环境暴露对羟基苯甲酸酯和精液质量参数之间的关联[主要精液参数，计算机辅助精液分析（CASA参数），精子染色质结构，以及男性生殖激素水平[卵泡刺激素（FSH），睾酮，雌二醇]。方法：尿液样本收集315名男性参加不孕症诊所诊断目的与正常精液浓度为15至300 mln/mL的5个对羟基苯甲酸酯浓度进行了分析，使用一种有效的气相色谱离子抽头质谱法。参与者进行了采访，并提供了精液，唾液，和血液samples.Results：尿中的尼泊金酯浓度显着相关的精子形态异常的百分比增加，在精子的高DNA含量和减少的百分比活力和睾酮level.Conclusions：这是第一个研究这个话题，所以尼泊金酯和精液质量之间的关系的观察值得进一步调查。
Objective:The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol].Methods:Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples.Results:Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level.Conclusions:This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.