Pulmonary Retransplantation for Obliterative Bronchiolitis
Pulmonary Retransplantation for Obliterative Bronchiolitis
复制标题
闭塞性细支气管炎的肺再移植
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
G. Patterson
中科院分区：
文献类型：
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作者：
R. Novick;H. Schäfers;L. Stitt;B. Andréassian;W. Klepetko;R. Hardesty;A. Frost;G. Patterson
尽管肺移植受者的术后护理经验越来越丰富，但高达40%的患者在术后中期发生闭塞性细支气管炎（OB）。尽管一些患者对免疫抑制[1]、[3]增加有反应，但在许多其他患者中，慢性同种异体移植物功能障碍对治疗有耐药性，最终因进行性呼吸衰竭或机会性感染而死亡。自1988年以来，越来越多的OB肺移植患者接受再移植治疗[4]，b[12]。肺再移植登记于1991年建立，目的是记录结果并确定肺再移植后的生存预测因子[5]，[11]。最近，随着患者人数的增加，为了记录OB再移植后结果的决定因素，登记处数据进行了更新。
Despite increasing experience in the postoperative care of lung transplant recipients, obliterative bronchiolitis (OB) develops in up to 40% of patients in the intermediate term postoperatively[1],[2]. Although some patients with this condition respond to increased immunosuppression[1],[3], in many others chronic allograft dysfunction is resistant to therapy and ultimately causes death from progressive respiratory failure or opportunistic infection. Since 1988 an increasing number of lung transplant recipients with OB have been treated by retransplantation[4],[12]. The pulmonary retransplant registry was established in 1991 in order to document the results and determine the predictors of survival after pulmonary retransplantation[5],[11]. Recently, after increased patient accrual, the registry data were updated in order to document the determinants of outcome after retransplantation for OB.
组织学正常的同种异体肺移植物中存在供体特异性同种异体反应性可预测随后的闭塞性细支气管炎。
影响因子：
0.9
作者：
Zeevi,A;Rabinowich,H;Yousem,SA;Paradis,IL;Dauber,JH;Kormos,R;Armitage,J;Hardesty,R;Griffith,B;Duquesnoy,RJ
通讯作者：
Duquesnoy,RJ