Cytokine Profiles in Children with Severe Plasmodium falciparum Malaria in an Area of Unstable Malaria Transmission in Central Sudan
Cytokine Profiles in Children with Severe Plasmodium falciparum Malaria in an Area of Unstable Malaria Transmission in Central Sudan
复制标题
DOI：
10.1093/tropej/fmq109
复制
发表时间：
2011-10-01
影响因子：
2
通讯作者：
Adam, Ishag
中科院分区：
文献类型：
--
作者：
Mirghani, Hiba A.;Eltahir, Hatim G.;Adam, Ishag
背景：关于疟疾传播不稳定地区重症疟疾发病机制的数据很少。目的：该研究在苏丹中部的Senga医院进行，该医院的特点是疟疾传播不稳定，以调查严重恶性疟原虫疟疾儿童的细胞因子谱。研究方法：采用酶联免疫吸附试验测定三组儿童（每组31名）血清中三种细胞因子干扰素γ（IFN-γ）、白细胞介素-4（IL-4）和IL-10的浓度：患有一种或多种严重疟疾表现的儿童、患有单纯恶性疟原虫疟疾的儿童和健康对照组。结果：恶性疟重症患者IFN-γ和IL-10水平均显著升高。IFN-γ和IL-10之间存在中度正相关。结论：IFN-γ和IL-10在恶性疟患者血清中的高水平表达提示其在恶性疟发病机制中的作用。
Background: Few data exist concerning pathogenesis of severe malaria in areas of unstable malaria transmission. Objectives: The study was conducted in Senga hospital, central Sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in children with severe Plasmodium falciparum malaria. Methods: Enzyme-linked immunosorbent assay was used to measure the concentrations of three cytokines, interferon gamma (IFN-gamma), interleukin-4 (IL-4) and IL-10, in sera of three groups of children (31 in each arm): those with one or more manifestations of severe malaria, those children with uncomplicated P. falciparum malaria and healthy controls. Results: The levels of both IFN-gamma and IL-10 were significantly higher in patients with severe P. falciparum malaria. Medium positive correlations were observed between IFN-gamma and IL-10. Conclusion: Thus, the high levels of both IFN-gamma and IL-10 indicated their role in the pathogenesis of severe P. falciparum malaria.