Mechanics of enveloped virus entry into host cells.
Mechanics of enveloped virus entry into host cells.
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DOI：
10.1529/biophysj.105.074203
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发表时间：
2006
影响因子：
3.4
通讯作者：
Sean X. Sun;D. Wirtz
中科院分区：
文献类型：
--
作者：
Sean X. Sun;D. Wirtz
包膜病毒如HIV-1首先在细胞表面建立一个接触区，通过形成受体-配体复合物来稳定接触区，从而进入宿主。我们表明，有利的接触能量来自形成的受体复合物的相互作用区是足够的驱动吞噬的病毒的细胞。使用连续介质模型，我们表明，平衡吞噬深度和驱动力的吞噬病毒的大小和复杂的形成能量的函数。细胞骨架的弹性变形决定了细胞对吞噬的抵抗力。
Enveloped viruses such as HIV-1 enter their hosts by first establishing a contact region at the cell surface, which is stabilized by the formation of receptor-ligand complexes. We show that the favorable contact energy stemming from the formation of the receptor complexes in the interaction zone is sufficient to drive the engulfment of the virus by the cell. Using a continuum model, we show that the equilibrium engulfment depth and the force driving the engulfment are functions of the virus size and the complex formation energy. Resistance to engulfment is dominated by the elastic deformation of the cytoskeleton.