Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk
Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk
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DOI：
10.3390/nu11071552
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发表时间：
2019-07-01
期刊：
影响因子：
5.9
通讯作者：
Myint, Phyo Kyaw
中科院分区：
文献类型：
--
作者：
McCall, Stephen J.;Clark, Allan B.;Myint, Phyo Kyaw
背景资料：调查与维生素C缺乏相关的人口统计学和生活方式因素，并检查血浆维生素C水平与自我报告的身体功能健康之间的关系。方法：采用欧洲癌症前瞻性调查-诺福克研究，进行一项基于人群的横断面研究。血浆维生素C < 11 μ mol/L提示维生素C缺乏。非条件logistic回归模型评估了维生素C缺乏症与潜在危险因素之间的关联。评估了维生素C四分位数与通过36项简短问卷（SF-36）测量的自我报告的功能健康之间的关联。结果如下：调整后，维生素C缺乏症与年龄较大、男性、体力活动较少、吸烟、社会贫困地区（汤森指数）较多和受教育程度较低有关。与最高水平相比，维生素C水平最低的四分位数的人更有可能在身体功能的最低十分位中得分（校正比值比（aOR）：1.43（95%CI：1.21-1.70）），身体疼痛（aOR：1.29（95%CI：1.07-1.56））、一般健康（aOR：1.4（95%CI：1.18-1.66））和活力（aOR：1.23（95%CI：1.04-1.45））SF-36评分。结论：应针对有维生素C缺乏危险因素的人群采取简单的公共卫生干预措施。自我报告的功能健康状况不佳与血浆维生素C水平较低有关，这可能反映了潜伏性坏血病的症状。
Background: To investigate the demographic and lifestyles factors associated with vitamin C deficiency and to examine the association between plasma vitamin C level and self-reported physical functional health. Methods: A population-based cross-sectional study using the European Prospective Investigation into Cancer-Norfolk study. Plasma vitamin C level < 11 mu mol/L indicated vitamin C deficiency. Unconditional logistic regression models assessed the association between vitamin C deficiency and potential risk factors. Associations between quartiles of vitamin C and self-reported functional health measured by the 36-item short-form questionnaire (SF-36) were assessed. Results: After adjustment, vitamin C deficiency was associated with older age, being male, lower physical activity, smoking, more socially deprived area (Townsend index) and a lower educational attainment. Compared to the highest, those in the lowest quartile of vitamin C were more likely to score in the lowest decile of physical function (adjusted odds ratio (aOR): 1.43 (95%CI: 1.21-1.70)), bodily pain (aOR: 1.29 (95% CI: 1.07-1.56)), general health (aOR: 1.4 (95%CI: 1.18-1.66)), and vitality (aOR: 1.23 (95%CI: 1.04-1.45)) SF-36 scores. Conclusions: Simple public health interventions should be aimed at populations with risk factors for vitamin C deficiency. Poor self-reported functional health was associated with lower plasma vitamin C levels, which may reflect symptoms of latent scurvy.