High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results
High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results
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DOI：
10.1002/mpr.1459
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发表时间：
2015-03-01
影响因子：
3.1
通讯作者：
Rohde, Luis Augusto
中科院分区：
文献类型：
--
作者：
Salum, Giovanni Abrahao;Gadelha, Ary;Rohde, Luis Augusto
本研究的目的是介绍儿童精神障碍高危队列研究的基本原理、方法、设计和初步结果。我们描述了样本选择和研究的每个阶段的组成部分，其工具，任务和程序。初步结果仅限于基线阶段，包括：（i）用于增加儿童和家庭精神病理学频率的过采样程序的有效性;（ii）评分者间的可靠性和（iii）差异参与率的作用。共有来自57所学校的9937名儿童参加了甄别程序。其中2512例（随机=958例;高风险=1554例）使用诊断仪器进行了进一步评估。随机分层和高危分层儿童精神障碍患病率分别为19.9%和29.7%。过抽样程序是成功的，在选择一个样本的任何精神障碍的家庭率较高，根据诊断仪器。主要诊断工具的评定者间可靠性（Kappa）范围从0.72（多动障碍）到0.84（情绪障碍）。筛选工具成功地选择了一个具有高风险发展为精神障碍的子样本。这项研究可能有助于推动儿童精神病学领域的发展，并最终提供有用的临床信息。版权所有（c）2014约翰威利父子有限公司
The objective of this study is to present the rationale, methods, design and preliminary results from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders. We describe the sample selection and the components of each phases of the study, its instruments, tasks and procedures. Preliminary results are limited to the baseline phase and encompass: (i) the efficacy of the oversampling procedure used to increase the frequency of both child and family psychopathology; (ii) interrater reliability and (iii) the role of differential participation rate. A total of 9937 children from 57 schools participated in the screening procedures. From those 2512 (random =958; high risk =1554) were further evaluated with diagnostic instruments. The prevalence of any child mental disorder in the random strata and high-risk strata was 19.9% and 29.7%. The oversampling procedure was successful in selecting a sample with higher family rates of any mental disorders according to diagnostic instruments. Interrater reliability (kappa) for the main diagnostic instrument range from 0.72 (hyperkinetic disorders) to 0.84 (emotional disorders). The screening instrument was successful in selecting a sub-sample with high risk for developing mental disorders. This study may help advance the field of child psychiatry and ultimately provide useful clinical information. Copyright (c) 2014 John Wiley & Sons, Ltd.