Brief exposure to methamphetamine (METH) and phencyclidine (PCP) during late development leads to long-term learning deficits in rats.
Brief exposure to methamphetamine (METH) and phencyclidine (PCP) during late development leads to long-term learning deficits in rats.
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在晚期发育过程中，短暂暴露于甲基苯丙胺（METH）和苯基二酮（PCP）会导致大鼠长期学习缺陷。
DOI：
10.1016/j.brainres.2009.02.024
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发表时间：
2009-04-17
期刊：
影响因子：
2.9
通讯作者：
White W
中科院分区：
文献类型：
--
作者：
White IM;Minamoto T;Odell JR;Mayhorn J;White W
人们认为，在早期发育过程中接触甲基苯丙胺（METH）和苯环己哌啶（PCP）会导致后来的行为缺陷。我们假设在发育后期接触冰毒和五氯苯酚会产生类似的行为缺陷，特别是成年期的学习缺陷。 Wistar 大鼠在发育后期、出生后天数 (PD) 50-51 期间接受 METH (9 mg/kg)、PCP (9 mg/kg) 或生理盐水治疗，并检查随后的行为变化，包括：急性药物状态 (PD 50-51) 和药物后阶段 (PD 50-80) 期间的运动活动； PD 54-80 的社交互动；以及成年期的空间歧视和逆转（PD 90之后）。冰毒和五氯苯酚在急性状态下对运动的影响不同，但在药物后阶段则没有。 METH 在药物治疗后两周的整个测试中减少了社交互动，而 PCP 仅在测试的前 8 分钟内减少了社交互动。 METH 和 PCP 均不会损害空间辨别力的初始习得。然而，与对照组相比，PCP 显着损害了逆转，而 METH 则产生了轻微的缺陷。我们的数据提供的证据表明，在发育后期接触五氯苯酚和冰毒会导致成年后出现持久的认知缺陷。逆转的选择性损伤可能反映了由于早期接触药物而导致的前额皮质神经损伤。
Exposure to methamphetamine (METH) and phencyclidine (PCP) during early development is thought to produce later behavioral deficits. We postulated that exposure to METH and PCP during later development would produce similar behavioral deficits, particularly learning deficits in adulthood. Wistar rats were treated with METH (9 mg/kg), PCP (9 mg/kg), or saline during later development, postnatal days (PD) 50–51, and subsequent behavioral changes were examined including: locomotor activity during the acute drug state (PD 50–51) and the post-drug phase (PD 50–80); social interaction on PD 54–80; and spatial discrimination and reversal in adulthood (after PD 90). METH and PCP differentially affected locomotion during the acute state, but not during the post-drug phase. METH decreased social interaction throughout tests two weeks after drug treatment, whereas PCP decreased social interaction only during the first 8 min of tests. Neither METH nor PCP impaired initial acquisition of spatial discrimination. However, reversal was significantly impaired by PCP, whereas METH produced a mild deficit, compared to controls. Our data provide evidence that exposure to PCP and METH during later development lead to enduring cognitive deficits in adulthood. Selective impairment of reversal may reflect neurological damage in the prefrontal cortex due to early exposure to drugs.
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DOI：
10.1196/annals.1300.008
发表时间：
2003-01-01
期刊：
GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION
影响因子：
--
作者：
Farber, NB
通讯作者：
Farber, NB
影响因子：
5.3
作者：
Adams, B;Moghaddam, B
通讯作者：
Moghaddam, B
影响因子：
10.6
作者：
Farber, NB;Wozniak, DF;Olney, JW
通讯作者：
Olney, JW
影响因子：
2.9
作者：
Bisagno, V;Ferguson, D;Luine, VN
通讯作者：
Luine, VN
DOI：
10.1111/j.1749-6632.1996.tb17437.x
发表时间：
1996-01-01
期刊：
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE
影响因子：
--
作者：
Amano, T;Matsubayashi, H;Sasa, M
通讯作者：
Sasa, M