Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.
复制标题
色氨酸羟化酶基因的多态性可能与抑郁症患者的自杀行为有关。
DOI：
10.1176/ajp.154.10.1451
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Gelernter,J
中科院分区：
文献类型：
--
作者：
Mann,JJ;Malone,KM;Nielsen,DA;Goldman,D;Erdos,J;Gelernter,J
ESTA研究的目的是检验的假设，candonin系统相关的基因可能与自杀risk. MethodFifty 1无关的白人住院患者与抑郁症，有或没有自杀行为的历史，基因分型为一个双等位基因多态性在色氨酸羟化酶locus.ResultsThe不太常见的色氨酸羟化酶U等位基因发生在谁曾试图自杀的患者更大的频率。Logistic回归分析证实色氨酸羟化酶基因型和自杀attempts.ConclusionsSerotonergic-system-related基因的终身史之间的关联可能会影响自杀的风险在人与抑郁症。
ObjectiveThis study was designed to test the hypothesis that serotonin-system-related genes may be correlated with suicide risk.MethodFifty-one unrelated Caucasian inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the tryptophan hydroxylase locus.ResultsThe less common tryptophan hydroxylase U allele occurred with greater frequency in the patients who had attempted suicide. A logistic regression analysis confirmed an association between tryptophan hydroxylase genotype and lifetime history of suicide attempts.ConclusionsSerotonergic-system-related genes may influence the risk of suicide in persons with major depression.